Oghabi Bakhshaiesh Tayebeh, Majidzadeh-A Keivan, Esmaeili Rezvan
Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
DNA Repair (Amst). 2017 Jun;54:63-66. doi: 10.1016/j.dnarep.2017.03.004. Epub 2017 Mar 20.
The critical regulatory mechanisms in numerous cellular pathways including cell survival and DNA damage response mostly depend on phosphorylation and dephosphorylation of proteins. The serine/threonine phosphatase wild-type p53-induced phosphatase 1 (Wip1) is a growth-promoting phosphatase and its numerous downstream targets are important tumor suppressors. Here, we review the Wip1 activity and its relevance to cancer as an oncoprotein. Consecutive investigations about Wip1 and its relation to cancer is critical, as these studies ultimately contribute to the etiology of cancer. A number of innovative studies have recently investigated the importance of Wip1 as a new candidate for cancer diagnosis and prognosis. Accordingly, we discuss the present challenges of using Wip1 as a target for cancer treatment.
包括细胞存活和DNA损伤反应在内的众多细胞信号通路中的关键调节机制大多依赖于蛋白质的磷酸化和去磷酸化。丝氨酸/苏氨酸磷酸酶野生型p53诱导磷酸酶1（Wip1）是一种促进生长的磷酸酶，其众多下游靶点是重要的肿瘤抑制因子。在这里，我们综述Wip1的活性及其作为一种癌蛋白与癌症的相关性。对Wip1及其与癌症关系的持续研究至关重要，因为这些研究最终有助于癌症的病因学研究。最近，一些创新性研究调查了Wip1作为癌症诊断和预后新候选指标的重要性。因此，我们讨论了将Wip1作为癌症治疗靶点目前面临的挑战。
