Lee Katie Joanna, Clegg Peter David, Comerford Eithne Josephine, Canty-Laird Elizabeth Gail
Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.
Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK; School of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston CH64 7TE, UK; The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Liverpool, UK.
Stem Cells Int. 2017;2017:1919845. doi: 10.1155/2017/1919845. Epub 2017 Mar 12.
Ligament is prone to injury and degeneration and has poor healing potential and, with currently ineffective treatment strategies, stem cell therapies may provide an exciting new treatment option. Ligament-derived stem cell (LDSC) populations have been isolated from a number of different ligament types with the majority of studies focussing on periodontal ligament. To date, only a few studies have investigated LDSC populations in other types of ligament, for example, intra-articular ligaments; however, this now appears to be a developing field. This literature review aims to summarise the current information on nondental LDSCs including characteristics of LDSCs and their therapeutic potential. The stem cell niche has been shown to be vital for stem cell survival and function in a number of different physiological systems; therefore, the LDSC niche may have an impact on LDSC phenotype. The role of the LDSC niche on LDSC viability and function will be discussed as well as the therapeutic potential of LDSC niche modulation.
韧带容易受伤和退化，愈合潜力较差，并且由于目前的治疗策略效果不佳，干细胞疗法可能提供一种令人兴奋的新治疗选择。已经从多种不同类型的韧带中分离出韧带来源的干细胞（LDSC）群体，大多数研究集中在牙周韧带。迄今为止，只有少数研究调查了其他类型韧带中的LDSC群体，例如关节内韧带；然而，这现在似乎是一个正在发展的领域。这篇文献综述旨在总结目前关于非牙齿LDSC的信息，包括LDSC的特征及其治疗潜力。干细胞生态位已被证明在许多不同的生理系统中对干细胞的存活和功能至关重要；因此，LDSC生态位可能会影响LDSC表型。将讨论LDSC生态位对LDSC活力和功能的作用以及LDSC生态位调节的治疗潜力。
