格列吡嗪单剂量及多剂量治疗对正常大鼠和高血压大鼠中厄贝沙坦药代动力学和药效学的影响
Influence of Single and Multi Dose Treatment of Glipizide on Pharmacokinetics and Pharmacodynamics of Irbesartan in Normal and Hypertensive Rats.
作者信息
Anusha Adepu, Narendar Dudhipala, Krishna Murthy Boini, Goverdhan Puchchakayala
机构信息
Laboratory of Pharmacokinetics and Toxicokinetics, Department of Pharmacology, Vaagdevi College of Pharmacy, Kakatiya University, Warangal, Telangana, 506001, India.
Department of Pharmaceutics, Vaagdevi Institute of Pharmaceutical Sciences, Warangal, Telangana, 506005, India.
出版信息
High Blood Press Cardiovasc Prev. 2017 Jun;24(2):179-185. doi: 10.1007/s40292-017-0195-2. Epub 2017 Apr 6.
PURPOSE
The present study was carried out to investigate the pharmacokinetic and pharmacodynamic drug interaction of irbesartan with glipizide after single and multi dose treatment in normal and hypertensive rat models to evaluate the safety and effectiveness of the combination.
METHODS
The study was conducted on normal and 10% fructose solution induced hypertensive rats. Irbesartan and glipizide were administered orally for 7 days and on 8th day blood samples were collected for 12 h at regular time intervals from irbesartan alone and in combination with glipizide treated groups. The blood samples were analyzed for various pharmacokinetic and pharmacodynamic parameters.
RESULTS
Irbesartan caused marked reduction in blood pressure in hypertensive rats. The combination of irbesartan and glipizide in hypertensive rats produce significant change in blood pressure (pharmacodynamic) and also significance in pharmacokinetic parameters of irbesartan with glipizide in single dose and multiple doses.
CONCLUSION
The results of present study demonstrated that the synergistic activity of irbesartan with glipizide was observed.
目的
本研究旨在通过在正常大鼠和高血压大鼠模型中进行单剂量和多剂量治疗后，研究厄贝沙坦与格列吡嗪的药代动力学和药效学药物相互作用，以评估联合用药的安全性和有效性。
方法
本研究在正常大鼠和10%果糖溶液诱导的高血压大鼠上进行。口服给予厄贝沙坦和格列吡嗪7天，在第8天，从单独给予厄贝沙坦组以及与格列吡嗪联合治疗组，每隔一定时间采集12小时的血样。对血样进行各种药代动力学和药效学参数分析。
结果
厄贝沙坦可使高血压大鼠血压显著降低。在高血压大鼠中，厄贝沙坦与格列吡嗪联合用药在血压方面（药效学）产生显著变化，并且在单剂量和多剂量时，厄贝沙坦与格列吡嗪的药代动力学参数也有显著变化。
结论
本研究结果表明观察到了厄贝沙坦与格列吡嗪的协同活性。
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