Baima Jennifer, Omer Zehra B, Varlotto John, Yunus Shakeeb
Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School (UMMS), Worcester, MA, USA.
UMass Memorial Medical Center, 119 Belmont St, Worcester, MA, 01605-2982, USA.
Support Care Cancer. 2017 Sep;25(9):2809-2814. doi: 10.1007/s00520-017-3695-7. Epub 2017 Apr 6.
The purpose of this study is to evaluate compliance with and safety of a novel independent home exercise program for patients with high-grade brain tumors. We designed this program around the preferences and individual capabilities of this population as well as the potential barriers to exercise in cancer patients. Demographics were collected to better understand those that persisted with exercise.
Subjects with high-grade brain tumor received one-time training that included watching an exercise video and live demonstration of resistance band exercises, a balance exercise, and recommendations for walking. Subjects were instructed to do the exercises every day for 1 month. Main outcome measures were percentage of subjects who exercised throughout the month, frequency of exercising, demographic factors, quality of life scores (assessed by FACT-BR), and self report of adverse events.
Fourteen of the 15 (93%) subjects started the exercises during the course of the month. Nine of the fifteen (60%) continued the exercises throughout the month. Three additional subjects would have continued to exercise if formal or supervised rehabilitation had been offered. Among the subjects who continued the exercises regularly, higher frequency of exercising was significantly associated with living as married (p = 0.033), annual income >$50,000 (p = 0.047), scores of physical well-being (p = 0.047), and brain cancer specific well-being (p = 0.054) subscales. Among those who exercised frequently, there was also a trend towards increase in total FACT-BR scores (p = 0.059). The subjects who scored higher on the social well-being subscale of the FACT-BR at baseline self-reported a higher likelihood to continue the exercises after 1 month of participation in the study (p = 0.018). No adverse events were reported.
Our small group of subjects with high-grade brain tumors demonstrated compliance with and safety of a novel independent strength and balance exercise program in the home setting. Higher frequency of exercising was associated with life quality parameters as well as marriage and income.
本研究旨在评估一项针对高级别脑肿瘤患者的新型独立家庭锻炼计划的依从性和安全性。我们围绕该人群的偏好、个人能力以及癌症患者锻炼的潜在障碍设计了这个计划。收集了人口统计学数据以更好地了解坚持锻炼的人群。
高级别脑肿瘤患者接受了一次培训，内容包括观看锻炼视频以及弹力带锻炼、平衡锻炼的现场演示，还有步行建议。受试者被要求每天进行锻炼，为期1个月。主要结局指标包括整个月都进行锻炼的受试者百分比、锻炼频率、人口统计学因素、生活质量评分（通过FACT-BR评估）以及不良事件的自我报告。
15名受试者中有14名（93%）在当月开始了锻炼。15名受试者中有9名（60%）整个月都持续进行锻炼。如果提供正式或有监督的康复治疗，另外3名受试者也会继续锻炼。在定期锻炼的受试者中，较高的锻炼频率与已婚状态（p = 0.033）、年收入>50,000美元（p = 0.047）、身体健康评分（p = 0.047）以及脑癌特异性健康评分（p = 0.054）子量表显著相关。在经常锻炼的人群中，FACT-BR总分也有增加的趋势（p = 0.059）。在基线时FACT-BR社会健康子量表得分较高的受试者自我报告称，参与研究1个月后继续锻炼的可能性更大（p = 0.018）。未报告不良事件。
我们这一小群高级别脑肿瘤受试者证明了一种新型独立的家庭力量和平衡锻炼计划的依从性和安全性。较高的锻炼频率与生活质量参数以及婚姻和收入相关。
