Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Wien Klin Wochenschr. 2012 Jun;124(11-12):377-83. doi: 10.1007/s00508-012-0186-1. Epub 2012 Jun 12.
Aim of this study was to describe longitudinal assessments of handgrip strength, strength of thigh muscles, and self-reported physical performance in patients with glioblastoma after neurosurgical intervention undergoing chemoradiation.
Strength testing was performed in 24 Austrian glioblastoma patients (m:f = 19:5, 52 ± 14a, BMI = 26 ± 3 kg/m²) at baseline and follow up after chemoradiation (interval between baseline and follow up = 14 ± 9 weeks). Isokinetic testing of knee extension/flexion was performed by using a Biodex 3 dynamometer. Handgrip strength was measured by using a Jamar hand-dynamometer. Physical performance was assessed by using the subscales "physical functioning" and "role physical" of the SF-36 Health Survey.
Peak torque of knee extensors (peak torque) were clearly lower than expected for age- and sex-related values (p < 0.0001). In comparison with age- and sex-related reference values, deficits of "role physical" (p < 0.0001) and "physical functioning" (p = 0.010) were found. Effects of measurements of muscle strength on "physical functioning" were significant (peak torque:p < 0.001; handgrip strength:p < 0.001). No significant change could be detected after follow up for peak torque (p = 0.337), handgrip strength (p = 0.995), "physical functioning" (p = 0.824), and "role physical" (0.594).
In this study, notable deficits especially in muscular strength of thigh muscles and general physical performance of patients with glioblastoma have been found before and after chemoradiation. Reduced muscle strength and impaired self-reported physical performance seem to be clinically relevant functional deficits in (Austrian) glioblastoma patients. Therefore, rehabilitation and supportive care should also include options to increase muscle strength.
本研究旨在描述神经外科干预后行放化疗的胶质母细胞瘤患者的握力、大腿肌肉力量和自我报告的身体机能的纵向评估。
在基线和放化疗后随访时（基线和随访之间的间隔为 14±9 周），对 24 名奥地利胶质母细胞瘤患者（m：f=19：5，52±14a，BMI=26±3kg/m²）进行了力量测试。使用 Biodex 3 测力计进行膝关节屈伸等速测试。使用 Jamar 握力计测量握力。使用 SF-36 健康调查的“身体机能”和“角色身体”子量表评估身体机能。
膝关节伸肌的峰值扭矩（峰值扭矩）明显低于年龄和性别相关值（p<0.0001）。与年龄和性别相关的参考值相比，“角色身体”（p<0.0001）和“身体机能”（p=0.010）存在缺陷。肌肉力量测量对“身体机能”的影响具有统计学意义（峰值扭矩：p<0.001；握力：p<0.001）。随访后，峰值扭矩（p=0.337）、握力（p=0.995）、“身体机能”（p=0.824）和“角色身体”（0.594）均未检测到显著变化。
本研究发现，胶质母细胞瘤患者在放化疗前后均存在明显的大腿肌肉力量和一般身体机能缺陷。肌肉力量下降和自我报告的身体机能受损似乎是（奥地利）胶质母细胞瘤患者的临床相关功能缺陷。因此，康复和支持性护理还应包括增加肌肉力量的选择。
