Karakus Kadir, Kunt Refik, Memis Cagdas O, Kunt Duygu A, Dogan Bilge, Ozdemiroglu Filiz, Sevincok Levent
Department of Psychiatry, Medical School, Adnan Menderes University, Aydin, Turkey.
Department of Neurology, Neurology Division, Aydin State Hospital, Aydin, Turkey.
Psychogeriatrics. 2017 Nov;17(6):414-422. doi: 10.1111/psyg.12266. Epub 2017 Apr 7.
The biological and psychological aspects of post-stroke depression (PSD) may vary based on the time since stroke onset. The sociodemographic and clinical correlates of early-onset PSD are not yet well understood. In the present study, we aimed to investigate the clinical correlates of early-onset depression following first stroke. We hypothesized that the severity of a stroke or disability (other than lesion characteristics) would likely be related to PSD in a sample of first stroke patients with single and unilateral lesions.
Post-stroke patients with (n = 40) and without (n = 51) early-onset depression were compared with respect to several demographic and clinical variables.
There were no significant differences between the groups with respect to lesion location, lateralization, or volume. Scores on the Brief Disability Questionnaire, National Institutes of Health Stroke Scale, and Modified Rankin Scale were significantly higher in depressed post-stroke patients than in non-depressed patients. The anxiety, depression, and total scores of the Hospital Anxiety and Depression Scale were positively correlated with the Modified Rankin Scale, National Institutes of Health Stroke Scale, and Brief Disability Questionnaire scores. A previous history of depression and Brief Disability Questionnaire score were strongly associated with the occurrence of early-onset PSD.
Our findings suggest that early-onset PSD is likely to be correlated with the severity of stroke and functional disability.
卒中后抑郁（PSD）的生物学和心理学方面可能因卒中发病后的时间不同而有所差异。早发性PSD的社会人口学和临床相关因素尚未得到充分了解。在本研究中，我们旨在调查首次卒中后早发性抑郁的临床相关因素。我们假设，在首次发生单侧单病灶卒中的患者样本中，卒中或残疾的严重程度（不包括病灶特征）可能与PSD有关。
比较了有（n = 40）和没有（n = 51）早发性抑郁的卒中后患者的一些人口统计学和临床变量。
两组在病灶位置、侧别或体积方面无显著差异。卒中后抑郁患者的简易残疾问卷、美国国立卫生研究院卒中量表和改良Rankin量表得分显著高于非抑郁患者。医院焦虑抑郁量表的焦虑、抑郁和总分与改良Rankin量表、美国国立卫生研究院卒中量表和简易残疾问卷得分呈正相关。既往抑郁史和简易残疾问卷得分与早发性PSD的发生密切相关。
我们的研究结果表明，早发性PSD可能与卒中严重程度和功能残疾有关。
