Kiehna Erin N, Arnush Maxine R, Tamrazi Benita, Cotter Jennifer A, Hawes Debra, Robison Nathan J, Fong Cindy Y, Estrine Dolores B, Han Jennifer H, Biegel Jaclyn A
Departments of 1 Neurosurgery.
University of California, Berkeley, California.
J Neurosurg Pediatr. 2017 Jul;20(1):51-55. doi: 10.3171/2017.2.PEDS16679. Epub 2017 Apr 7.
Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.
小儿高级别胶质瘤是一种死亡率很高的罕见肿瘤。作者报告了首例小儿患者中与GOPC(FIG)-ROS1融合相关的高级别胶质瘤病例。该患者4岁时接受了肿瘤全切除，随后进行辅助大剂量化疗及自体造血干细胞挽救治疗。移植后30个月，她仍无疾病复发。
