一名儿童高级别胶质瘤幸存者中发现新型GOPC(FIG)-ROS1融合基因。
Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor.
作者信息
Kiehna Erin N, Arnush Maxine R, Tamrazi Benita, Cotter Jennifer A, Hawes Debra, Robison Nathan J, Fong Cindy Y, Estrine Dolores B, Han Jennifer H, Biegel Jaclyn A
机构信息
Departments of 1 Neurosurgery.
University of California, Berkeley, California.
出版信息
J Neurosurg Pediatr. 2017 Jul;20(1):51-55. doi: 10.3171/2017.2.PEDS16679. Epub 2017 Apr 7.
Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.
小儿高级别胶质瘤是一种死亡率很高的罕见肿瘤。作者报告了首例小儿患者中与GOPC(FIG)-ROS1融合相关的高级别胶质瘤病例。该患者4岁时接受了肿瘤全切除，随后进行辅助大剂量化疗及自体造血干细胞挽救治疗。移植后30个月，她仍无疾病复发。
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