ESCRT 调控细胞坏死性凋亡
ESCRTing Necroptosis.
机构信息
Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Heath San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Heath San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
出版信息
Cell. 2017 Apr 6;169(2):186-187. doi: 10.1016/j.cell.2017.03.030.
Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
细胞程序性坏死是一种由 MLKL 介导的细胞膜破坏而导致的高度炎症形式的细胞死亡。在本期《细胞》杂志中，龚等人通过鉴定对抗细胞程序性坏死的机制，维持质膜完整性并延长细胞存活时间，挑战了 MLKL 激活是一个不可逆转的观点。
Zotero 插件