Gleiter C H, Nutt D J
Laboratory of Clinical Studies, DICBR, National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD 20892.
Psychopharmacology (Berl). 1988;95(1):68-70. doi: 10.1007/BF00212769.
The effects of repeated electroconvulsive shock on the 5-HT uptake site were studied in rat cortex using [3H]-paroxetine binding. This ligand was used because it is thought to directly label the 5-HT uptake site, whereas [3H]-imipramine may bind to a presynaptic recognition site different from the uptake site. No changes were found in the maximum number of [3H]-paroxetine binding sites and equilibrium dissociation constant after repeated electroconvulsive shock, whereas a parallel investigation of beta-adrenoceptor binding showed the expected decrease in receptor number.
利用[3H] - 帕罗西汀结合法，在大鼠皮层中研究了重复电惊厥休克对5 - 羟色胺（5 - HT）摄取位点的影响。使用这种配体是因为它被认为可直接标记5 - HT摄取位点，而[3H] - 丙咪嗪可能与不同于摄取位点的突触前识别位点结合。重复电惊厥休克后，[3H] - 帕罗西汀结合位点的最大数量和平衡解离常数未发现变化，而对β - 肾上腺素能受体结合的平行研究显示受体数量出现预期的减少。
