Pérez Gago M C, Saavedra Santa Gadea O, de la Cruz-Merino L
Servicio de Oncología Médica, Hospital Universitario Virgen Macarena, Sevilla, España.
Servicio de Oncología Médica, Hospital Universitario Virgen Macarena, Sevilla, España.
Actas Dermosifiliogr. 2017 Oct;108(8):721-728. doi: 10.1016/j.ad.2017.01.016. Epub 2017 Apr 25.
Metastatic or locally advanced unresectable melanoma carries a high morbidity and mortality. However, notable advances have been made in recent years in the systemic treatment of this disease, with the appearance of targeted therapy using tyrosine kinase inhibitors that block the mitogen activated protein kinase pathway, and of modern immunotherapy with immune-modulating monoclonal antibodies. In this paper, we provide an update of available data on new immune therapies and we review the clinical development that led to their approval for use in routine clinical practice.
转移性或局部晚期不可切除的黑色素瘤具有较高的发病率和死亡率。然而，近年来，随着阻断丝裂原活化蛋白激酶途径的酪氨酸激酶抑制剂靶向治疗以及免疫调节单克隆抗体现代免疫疗法的出现，该疾病的全身治疗取得了显著进展。在本文中，我们提供了关于新型免疫疗法的现有数据更新，并回顾了使其获批用于常规临床实践的临床研发情况。
