肠道病毒和鼻病毒5'非编码区的比较序列分析。

Comparative sequence analysis of the 5' noncoding region of the enteroviruses and rhinoviruses.

作者信息

Rivera V M, Welsh J D, Maizel J V

机构信息

Program Resources, Inc., NCI-FCRF, Frederick, Maryland 21701.

出版信息

Virology. 1988 Jul;165(1):42-50. doi: 10.1016/0042-6822(88)90656-3.

DOI:10.1016/0042-6822(88)90656-3

PMID:2838971

Abstract

A comparative sequence analysis of the 5' noncoding region of a subgroup of the picornaviruses, including the polioviruses, coxsackie B3, and the human rhinoviruses, reveals the conservation of certain features despite the divergence of sequence. In this subgroup, for which nine complete sequences are available, two long stretches of sequence, two pyrimidine-rich regions, and 22 hairpins are conserved. Based on these results, similar secondary structures encompassing the entire 5' noncoding regions of these viruses are predicted. The fact that sequence divergence occurred only in a manner that allowed conservation of these structures implicates a biologically functional role for this region. The possible roles it may have in the picornavirus life cycle are discussed.

摘要

对一组小核糖核酸病毒（包括脊髓灰质炎病毒、柯萨奇B3病毒和人鼻病毒）的5'非编码区进行的比较序列分析表明，尽管序列存在差异，但某些特征仍具有保守性。在这个有九个完整序列的亚组中，有两段长序列、两个富含嘧啶的区域和22个发夹结构是保守的。基于这些结果，预测了包含这些病毒整个5'非编码区的相似二级结构。序列差异仅以允许这些结构保守的方式发生，这一事实暗示了该区域具有生物学功能作用。文中讨论了它在小核糖核酸病毒生命周期中可能具有的作用。