University Federico II of Naples, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Naples, Italy.
Melbourne Dental School, University of Melbourne, Carlton, Vic, Australia.
J Oral Pathol Med. 2017 Oct;46(9):810-816. doi: 10.1111/jop.12577. Epub 2017 Jun 5.
To analyze intra, extra-oral symptoms and psychological profiles in symptomatic patients with reticular (R) forms of oral lichen planus (OLP).
Thirty symptomatic R-OLP (sR-OLP) patients were compared with an equal number of non-symptomatic R-OLP (nsR-OLP) patients, burning mouth syndrome (BMS) patients, and healthy subjects (HS). The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), and the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) were administered. Descriptive statistics, the non-parametric ANOVA procedure by Kruskal-Wallis, the exact Fisher test, and the multiple comparison test by the Mann-Whitney U test were performed.
The median and IQR of the HAM-D and HAM-A were 16.0 (11.7-24.0) and 17.5 (13.7-27.2) for the BMS, 13.5 (12.0-15.0) and 15.5 (10.7-18.0) for the sR-OLP patients, 2.0 (2.0-3.2) and 2.0 (2.0-4.0) for the nsR-OLP patients, and 3.0 (2.0-4.0) and 3.0 (2.0-4.0) for the HS, respectively. The median and IQR of the NRS and T-PRI were 9.0 (7.7-10.0) and 11.0 (9.0-12.2) for the BMS and 9.0 (7.7-10.0) and 11.5 (7.0-13.0) for the sR-OLP patients, respectively. Comparison analysis between the BMS and sR-OLP patients revealed a non-significant difference between the medians of the psychological profile and pain in the two groups (P-value>.05).
The oral complaints are correlated with anxious and depressive symptoms in sR-OLP patients. Mood disorders could modulate the pain perception or that patients could develop two different associated oral diseases, OLP and BMS.
分析网状型口腔扁平苔藓（OLP）患者的口腔内外症状和心理特征。
将 30 例有症状的网状型 OLP（sR-OLP）患者与相同数量的无症状网状型 OLP（nsR-OLP）患者、灼口综合征（BMS）患者和健康受试者（HS）进行比较。采用数字评分量表（NRS）、总疼痛评分指数（T-PRI）、汉密尔顿抑郁量表（HAM-D）和汉密尔顿焦虑量表（HAM-A）进行评估。采用描述性统计、Kruskal-Wallis 非参数 ANOVA 程序、确切 Fisher 检验和 Mann-Whitney U 检验的多重比较检验。
BMS 的 HAM-D 和 HAM-A 的中位数和 IQR 分别为 16.0（11.7-24.0）和 17.5（13.7-27.2），sR-OLP 患者分别为 13.5（12.0-15.0）和 15.5（10.7-18.0），nsR-OLP 患者分别为 2.0（2.0-3.2）和 2.0（2.0-4.0），HS 分别为 3.0（2.0-4.0）和 3.0（2.0-4.0）。BMS 和 sR-OLP 患者的 NRS 和 T-PRI 的中位数和 IQR 分别为 9.0（7.7-10.0）和 11.0（9.0-12.2），sR-OLP 患者分别为 9.0（7.7-10.0）和 11.5（7.0-13.0）。BMS 和 sR-OLP 患者的心理状况和疼痛中位数之间的比较分析显示两组之间无显著差异（P 值>.05）。
sR-OLP 患者的口腔症状与焦虑和抑郁症状相关。情绪障碍可能会调节疼痛感知，或者患者可能会同时患上两种不同的口腔疾病，即 OLP 和 BMS。
