眼眶尖综合征累及头颈癌患者：病例系列
Orbital apex syndrome affecting head and neck cancer patients: A case series.
作者信息
Prado-Ribeiro A-C, Luiz A-C, Montezuma M-A, Mak M-P, Santos-Silva A-R, Brandão T-B
机构信息
Instituto do Câncer do Estado de São Paulo, Avenida Doutor Arnaldo, 251, Segundo Andar - Sala 75, São Paulo - SP, Brasil,
出版信息
Med Oral Patol Oral Cir Bucal. 2017 May 1;22(3):e354-e358. doi: 10.4317/medoral.21506.
BACKGROUND
Orbital apex syndrome (OAS) is a complex and uncommon disorder that typically damages multiple cranial nerves in association with optic nerve dysfunction. OAS is associated with several different pathologies, however; only a few cases have been reported in association with head and neck cancer (HNC) so far.
MATERIAL AND METHODS
A case series of HNC patients diagnosed with OAS is described including clinicopathological data, image findings, and disease outcome.
RESULTS
Ptosis and diplopia were diagnosed in four male patients with mean age of 61.2 years who were undergoing treatment for late-stage carcinomas of the tongue, larynx, and nasopharynx, eventually leading to the diagnosis of OAS. The mean overall survival rate after the diagnosis of OAS was 9.5 months.
CONCLUSIONS
The current study reinforces evidence that OAS indicates poor prognosis and highlights the importance of early diagnosis.
背景
眶尖综合征（OAS）是一种复杂且罕见的疾病，通常会在视神经功能障碍的同时损害多条颅神经。然而，OAS与多种不同的病理情况相关；迄今为止，仅有少数病例报告与头颈癌（HNC）相关。
材料与方法
描述了一系列被诊断为OAS的HNC患者的病例，包括临床病理数据、影像检查结果及疾病转归。
结果
4名平均年龄为61.2岁的男性患者在接受舌、喉和鼻咽癌晚期治疗时被诊断出上睑下垂和复视，最终确诊为OAS。OAS诊断后的平均总生存率为9.5个月。
结论
本研究进一步证实了OAS提示预后不良的证据，并强调了早期诊断的重要性。
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