来自垂穗石松的对黄嘌呤氧化酶有抑制作用的新木脂素和锯齿烷三萜类化合物。
Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua.
作者信息
Li Jing, Xu Ping-Sheng, Tan Lei-Hong, Zou Zhen-Xing, Wang Yi-Kun, Long Hong-Ping, Zhou Gan, Li Guang, Xu Kang-Ping, Tan Gui-Shan
机构信息
Xiangya Hospital of Central South University, Changsha 410008, PR China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
Xiangya Hospital of Central South University, Changsha 410008, PR China.
出版信息
Fitoterapia. 2017 Jun;119:45-50. doi: 10.1016/j.fitote.2017.04.005. Epub 2017 Apr 5.
Three new neolignans, lycocernuasides B-D (1-3), three new serratane triterpenoids, lycernuic ketones D (8) and E (9), and lycernuic A (10), together with six known compounds, were isolated from the 75% aqueous EtOH extract of Palhinhaea cernua. Their structures and absolute configurations were established primarily by NMR, HRESIMS and circular dichroism (CD). All compounds were evaluated the inhibitory activities of xanthine oxidase. Compounds 1-3 displayed moderate inhibitory effects on xanthine oxidase with IC values of 30.36μM, 42.65μM and 35.33μM, respectively.
从石松（Palhinhaea cernua）的75%乙醇水溶液提取物中分离得到了三种新的新木脂素，即石松苷B-D（1-3），三种新的锯齿烷三萜类化合物，即石松酮D（8）和E（9）以及石松A（10），还有六种已知化合物。它们的结构和绝对构型主要通过核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）和圆二色光谱（CD）确定。对所有化合物进行了黄嘌呤氧化酶抑制活性评估。化合物1-3对黄嘌呤氧化酶表现出中等抑制作用，其半数抑制浓度（IC）值分别为30.36μM、42.65μM和35.33μM。
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