来自鳞叶卷瓣兰的角倍三萜类化合物。
Serratene-type triterpenoids from Palhinhaea cernua.
机构信息
State Key Laboratory of Drug Research, Shanghai, Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China.
State Key Laboratory of Drug Research, Shanghai, Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China.
出版信息
Fitoterapia. 2018 Jun;127:151-158. doi: 10.1016/j.fitote.2018.02.011. Epub 2018 Feb 12.
Phytochemical investigation of the 95% ethanol extract of the whole plant of Palhinhaea cernua afforded five new serratene-type triterpenoids (1-5) together with four known analogues (6-9). The structures of the new compounds were elucidated by extensive spectroscopic analysis and X-ray crystallographic data. Compounds 1-3 triggered apoptosis of Hela cell with EC values of 3.49 ± 0.05, 0.28 ± 0.13 and 7.98 ± 0.03 μM, respectively.
对全株毛叶巴豆的 95%乙醇提取物进行植物化学研究，得到了五个新的锯齿状三萜（1-5）和四个已知类似物（6-9）。通过广泛的光谱分析和 X 射线晶体学数据阐明了新化合物的结构。化合物 1-3 分别以 EC 值为 3.49±0.05、0.28±0.13 和 7.98±0.03µM 诱导 Hela 细胞凋亡。
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