Scheiber C, Kiss R, De Launoit Y, Frühling J
Service de Radiothérapie et de Médecine Nucléaire, Institut J. Bordet, Centre des Tumerurs de l'Université Libre de Bruxelles, Belgium.
Anticancer Res. 1988 May-Jun;8(3):403-7.
The effects induced by a low dose cyclophosphamide treatment (CPA) along with an attempt of estradiol-17-beta (E2) cell recruitment, on the bioenergetics and the phosphomonoesters/phosphodiesters (PME/PDE) ratio in the transplantable MXT mouse mammary tumor have been studied by 31P-NMR spectroscopy in vivo. Our results show that neither ovariectomy (OO) nor the additional low dose E2 + CPA treatment significantly decreased tumor growth, whilst E2 + CPA treatment induced significant modifications compared to values recorded in tumors grafted on intact or ovariectomized animals, of all peak height ratios but PME/PDE, which further remained at a constant value during tumor growth.
通过体内31P-NMR光谱研究了低剂量环磷酰胺处理（CPA）以及雌二醇-17-β（E2）细胞募集尝试对可移植MXT小鼠乳腺肿瘤生物能量学和磷酸单酯/磷酸二酯（PME/PDE）比率的影响。我们的结果表明，卵巢切除术（OO）和额外的低剂量E2 + CPA处理均未显著降低肿瘤生长，而与移植到完整或去卵巢动物体内的肿瘤所记录的值相比，E2 + CPA处理诱导了除PME/PDE之外的所有峰高比率的显著变化，PME/PDE在肿瘤生长过程中进一步保持恒定值。
