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微小RNA在炎症性肠病中的作用

Role of MiRNAs in Inflammatory Bowel Disease.

作者信息

Cao Bo, Zhou Xin, Ma Jiaojiao, Zhou Wei, Yang Wanli, Fan Daiming, Hong Liu

机构信息

The First Brigade of Student, Fourth Military Medical University, Xi'an, Shaanxi Province, China.

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

出版信息

Dig Dis Sci. 2017 Jun;62(6):1426-1438. doi: 10.1007/s10620-017-4567-1. Epub 2017 Apr 8.

DOI:10.1007/s10620-017-4567-1
PMID:28391412
Abstract

Inflammatory bowel diseases (IBD), mainly including Crohn's disease and ulcerative colitis, are characterized by chronic inflammation of the gastrointestinal tract. Despite improvements in detection, drug treatment and surgery, the pathogenesis of IBD has not been clarified. A number of miRNAs have been found to be involved in the initiation, development and progression of IBD, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the roles of miRNAs in IBD and analyzed the contribution of miRNAs to general diagnosis, differential diagnosis and activity judgment of IBD. Furthermore, we have also elaborated the promising role of miRNAs in IBD-related cancer prevention and prognosis prediction.

摘要

炎症性肠病（IBD）主要包括克罗恩病和溃疡性结肠炎，其特征为胃肠道的慢性炎症。尽管在检测、药物治疗和手术方面有所进展，但IBD的发病机制尚未阐明。已发现多种微小RNA（miRNA）参与IBD的起始、发展和进程，它们可能有潜力用作生物标志物和治疗靶点。在此，我们总结了miRNA在IBD中作用的最新进展，并分析了miRNA对IBD的一般诊断、鉴别诊断和活动度判断的贡献。此外，我们还阐述了miRNA在IBD相关癌症预防和预后预测中的潜在作用。

相似文献

[1]
Role of MiRNAs in Inflammatory Bowel Disease.

Dig Dis Sci. 2017-6

[2]
MicroRNAs as Innovative Biomarkers for Inflammatory Bowel Disease and Prediction of Colorectal Cancer.

Int J Mol Sci. 2022-7-20

[3]
MicroRNAs in inflammatory bowel disease: What do we know and what can we expect?

World J Gastroenterol. 2024-4-28

[4]
miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation.

World J Gastroenterol. 2016-2-21

[5]
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Int J Biol Sci. 2021

[6]
MicroRNAs: how many in inflammatory bowel disease?

Curr Opin Gastroenterol. 2016-7

[7]
MicroRNA signatures differentiate Crohn's disease from ulcerative colitis.

BMC Immunol. 2015-2-10

[8]
[Epithelial cell in intestinal homeostasis and inflammatory bowel diseases].

Med Sci (Paris). 2013-12

[9]
MicroRNA Biomarkers in IBD-Differential Diagnosis and Prediction of Colitis-Associated Cancer.

Int J Mol Sci. 2020-10-24

[10]
MiRNAs and inflammatory bowel disease: An interesting new story.

J Cell Physiol. 2018-11-11

引用本文的文献

[1]
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Saudi J Gastroenterol. 2025-7-1

[2]
MicroRNA signatures in the pathogenesis and therapy of inflammatory bowel disease.

Clin Exp Med. 2024-9-11

[3]
Biomarkers in inflammatory bowel disease: a practical guide.

Therap Adv Gastroenterol. 2024-5-9

[4]
MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements.

Biomedicines. 2024-1-5

[5]
Fecal miR-223 is a noninvasive biomarker for estimating Crohn's disease activity.

Immun Inflamm Dis. 2023-12

[6]
The role and mechanisms of miRNA in neonatal necrotizing enterocolitis.

Front Pediatr. 2022-11-28

[7]
Detection and Quantification of Immunoregulatory miRNAs in Human Milk and Infant Milk Formula.

BioTech (Basel). 2022-4-20

[8]
EpisomiR, a New Family of miRNAs, and Its Possible Roles in Human Diseases.

Biomedicines. 2022-5-30

[9]
The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability.

Cells. 2021-11-30

[10]
Integrated analysis of dysregulated microRNA and mRNA expression in intestinal epithelial cells following ethanol intoxication and burn injury.

Sci Rep. 2021-10-12

本文引用的文献

[1]
MicroRNA-142-5p contributes to Hashimoto's thyroiditis by targeting CLDN1.

J Transl Med. 2016-6-8

[2]
Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease.

FEBS J. 2016-7

[3]
Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract.

Int J Mol Sci. 2016-5-11

[4]
Deficiency of dietary niacin impaired gill immunity and antioxidant capacity, and changes its tight junction proteins via regulating NF-κB, TOR, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella).

Fish Shellfish Immunol. 2016-8

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Changing epidemiological trends of inflammatory bowel disease in Asia.

Intest Res. 2016-4

[6]
Up-regulation of Tight-Junction Proteins by p38 Mitogen-Activated Protein Kinase/p53 Inhibition Leads to a Reduction of Injury to the Intestinal Mucosal Barrier in Severe Acute Pancreatitis.

Pancreas. 2016-9

[7]
TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells.

PLoS One. 2016-4-27

[8]
Down-regulation of microRNAs of the miR-200 family and up-regulation of Snail and Slug in inflammatory bowel diseases - hallmark of epithelial-mesenchymal transition.

J Cell Mol Med. 2016-10

[9]
Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients.

Int J Mol Sci. 2016-4-19

[10]
Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease.

Genome Biol. 2016-3-30

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