感染HIV的孕妇中人类pegivirus的流行情况及垂直传播
Prevalence and vertical transmission of human pegivirus among pregnant women infected with HIV.
作者信息
Santos Lucas M, Lobato Rubens C, Barral Maria Fernanda M, Gonçalves Carla V, da Hora Vanusa P, Martinez Ana Maria B
机构信息
Laboratory of Molecular Biology, University Hospital, Universidade Federal do Rio Grande, Rio Grande, Brazil.
Medicine Faculty, University Hospital, Universidade Federal do Rio Grande, Rio Grande, Brazil.
出版信息
Int J Gynaecol Obstet. 2017 Jul;138(1):113-118. doi: 10.1002/ijgo.12175. Epub 2017 May 3.
OBJECTIVE
To determine the prevalence of human pegivirus (HPgV) and factors associated with vertical transmission among pregnant women infected with HIV.
METHOD
A retrospective cross-sectional study was conducted among pregnant women treated at an HIV reference service in Rio Grande, Brazil, between January 1, 2010, and January 1, 2015. The polymerase chain reaction was used to diagnose HPgV infection among the women and their neonates. Clinical, obstetric, and neonatal data were obtained from medical records.
RESULTS
Infection with HPgV was detected among 16 (25%) of 63 women and 5 (8%) of 63 newborns, corresponding to a vertical transmission rate of 31%. Multivariate analysis demonstrated that the absence of prenatal care was the only risk factor for vertical transmission of HPgV (prevalence ratio 19.61, 95% confidence interval 1.29-297.48; P=0.032).
CONCLUSION
Prenatal care could protect against vertical transmission of HPgV among women infected with HIV; however, studies among HIV-negative individuals are still required to verify this correlation.
目的
确定感染人类pegivirus（HPgV）的孕妇中HPgV的流行率以及与垂直传播相关的因素。
方法
对2010年1月1日至2015年1月1日期间在巴西里奥格兰德一家艾滋病参考服务机构接受治疗的孕妇进行了一项回顾性横断面研究。采用聚合酶链反应诊断这些妇女及其新生儿中的HPgV感染。临床、产科和新生儿数据从病历中获取。
结果
63名妇女中有16名（25%）和63名新生儿中有5名（8%）检测出感染HPgV，垂直传播率为31%。多变量分析表明，未进行产前护理是HPgV垂直传播的唯一危险因素（患病率比值19.61，95%置信区间1.29 - 297.48；P = 0.032）。
结论
产前护理可预防感染HIV的妇女中HPgV的垂直传播；然而，仍需要对HIV阴性个体进行研究以验证这种相关性。
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