Aljenedil Sumayah, Hegele Robert A, Genest Jacques, Awan Zuhier
Department of Cardiology and Research Institute, McGill University Health Center, Montreal, Quebec, Canada.
Department of Endocrinology and Metabolism, Robarts Research Institute, London, Ontario, Canada.
J Clin Lipidol. 2017 Jan-Feb;11(1):297-300. doi: 10.1016/j.jacl.2016.12.006. Epub 2016 Dec 23.
Estrogen, whether therapeutic or physiologic, can cause hypertriglyceridemia. Hypertriglyceridemia-induced pancreatitis is a rare complication.
We report 2 women who developed estrogen-associated severe hypertriglyceridemia with pancreatitis. The first patient developed pancreatitis secondary to hypertriglyceridemia associated with in vitro fertilization cycles. Marked reduction in her triglyceride was achieved with dietary restrictions and fibrate. The second patient developed pancreatitis secondary to hypertriglyceridemia during her pregnancies. She was noncompliant with the treatment; therefore, her triglyceride remained high after delivery. In both patients, no hypertriglyceridemia-associated genes mutations were identified, although the second patient had strong polygenic susceptibility to hypertriglyceridemia.
Estrogen-induced severe hypertriglyceridemia with pancreatitis can be a life-threatening condition. Screening in high-risk patients is crucial to prevent subsequent complications.
雌激素，无论是治疗性的还是生理性的，都可导致高甘油三酯血症。高甘油三酯血症诱发的胰腺炎是一种罕见的并发症。
我们报告了2例发生雌激素相关严重高甘油三酯血症并伴有胰腺炎的女性患者。首例患者因与体外受精周期相关的高甘油三酯血症继发胰腺炎。通过饮食限制和贝特类药物，其甘油三酯水平显著降低。第二例患者在孕期因高甘油三酯血症继发胰腺炎。她未遵医嘱治疗；因此，产后其甘油三酯水平仍居高不下。在这2例患者中，均未发现与高甘油三酯血症相关的基因突变，尽管第二例患者对高甘油三酯血症有很强的多基因易感性。
雌激素诱发的严重高甘油三酯血症并伴有胰腺炎可能是一种危及生命的疾病。对高危患者进行筛查对于预防后续并发症至关重要。
