Lack E E, Upton M P
Department of Pathology, Children's Hospital, Boston.
Arch Otolaryngol Head Neck Surg. 1988 Aug;114(8):898-906. doi: 10.1001/archotol.1988.01860200082024.
During the 58-year period from 1928 through 1986, 80 patients 18 years of age or younger were treated or seen in consultation at Children's Hospital, Boston, for an epithelial or nonepithelial tumor of salivary gland origin. Using established criteria, ten (40%) of the 25 epithelial tumors were pleomorphic adenomas and the remaining tumors were classified as histologically malignant growths including mucoepidermoid carcinoma (n = 6), acinic cell carcinoma (n = 5), and adenocarcinoma most likely of duct cell origin (n = 2). Two other carcinomas presented as congenital parotid salivary gland tumors in newborns and were considered to have biphasic composition including both epithelial and myoepithelial cells, with the latter type predominating. There was only one tumor-related death due to metastases among the 15 children with malignant epithelial tumors (7%); four other patients experienced a local recurrence of tumor (27%). Of the 55 nonepithelial tumors, capillary hemangioma was the most common and showed distinct predilection for female infants with localization in the left parotid gland. The histologic spectrum of primary salivary gland tumors in infancy and childhood is distinctive and merits careful correlation with therapeutic strategies.
在1928年至1986年的58年期间，80名18岁及以下的患者因涎腺来源的上皮性或非上皮性肿瘤在波士顿儿童医院接受治疗或会诊。根据既定标准，25例上皮性肿瘤中有10例（40%）为多形性腺瘤，其余肿瘤被分类为组织学上的恶性肿瘤，包括黏液表皮样癌（n = 6）、腺泡细胞癌（n = 5）以及最可能起源于导管细胞的腺癌（n = 2）。另外两例癌表现为新生儿先天性腮腺涎腺肿瘤，被认为具有双相成分，包括上皮细胞和肌上皮细胞，后者占主导。15例恶性上皮性肿瘤患儿中仅有1例因转移导致肿瘤相关死亡（7%）；另外4例患者出现肿瘤局部复发（27%）。在55例非上皮性肿瘤中，毛细血管瘤最为常见，且明显好发于左侧腮腺的女婴。婴幼儿和儿童期原发性涎腺肿瘤的组织学谱具有独特性，值得与治疗策略进行仔细对照。
