Hvid L G, Nielsen M K F, Simonsen C, Andersen M, Caserotti P
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark (SDU), Odense, Denmark.
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark (SDU), Odense, Denmark.
Exp Gerontol. 2017 Jul;93:29-35. doi: 10.1016/j.exger.2017.03.019. Epub 2017 Apr 7.
Brain-derived neurotrophic factor (BDNF) is a potential important factor involved in neuroplasticity, and may be a mediator for eliciting adaptations in neuromuscular function and physical function in older individuals following physical training. As power training taxes the neural system to a very high extent, it may be particularly effective in terms of eliciting increases in systemic BDNF levels. We examined the effects of 12weeks of power training on mature BDNF (mBDNF) and total BDNF (tBDNF) in mobility-limited older adults from the Healthy Ageing Network of Competence (HANC) study. We included 47 older men and women: n=22 in the training group (TG: progressive high intensity power training, 2 sessions per week; age 82.7±5.4years, 55% women) and n=25 in the control group (CG: no interventions; age 82.2±4.5years, 76% women). Following overnight fasting, basal serum levels of mBDNF and tBDNF were assessed (human ELISA kits) at baseline and post-intervention. At baseline, mBDNF and tBDNF levels were comparable in the two groups, TG and CG. Post-intervention, no significant within-group or between-group changes were observed in mBDNF or tBDNF. Moreover, when divided into responder tertiles based upon changes in mBDNF and tBDNF (i.e. decliners, maintainers, improvers), respectively, comparable findings were observed for TG and CG. Altogether, basal systemic levels of serum mBDNF and tBDNF are not affected in mobility-limited older adults following 12-weeks of power training, and do not appear to be a major mechanistic factor mediating neuroplasticity in mobility-limited older adults.
脑源性神经营养因子（BDNF）是参与神经可塑性的一个潜在重要因素，可能是老年人进行体育锻炼后引起神经肌肉功能和身体功能适应性变化的一种介质。由于力量训练对神经系统的负荷程度非常高，在提高全身BDNF水平方面可能特别有效。我们在健康老龄化能力网络（HANC）研究中，研究了为期12周的力量训练对行动受限的老年人成熟BDNF（mBDNF）和总BDNF（tBDNF）的影响。我们纳入了47名老年男性和女性：训练组（TG）22人（进行渐进式高强度力量训练，每周2次；年龄82.7±5.4岁，女性占55%），对照组（CG）25人（不进行干预；年龄82.2±4.5岁，女性占76%）。在过夜禁食后，于基线和干预后评估基础血清mBDNF和tBDNF水平（使用人ELISA试剂盒）。在基线时，TG组和CG组的mBDNF和tBDNF水平相当。干预后，未观察到mBDNF或tBDNF在组内或组间有显著变化。此外，当分别根据mBDNF和tBDNF的变化分为反应者三分位数（即下降者、维持者、改善者）时，TG组和CG组的结果相当。总之，为期12周的力量训练对行动受限的老年人血清mBDNF和tBDNF的基础全身水平没有影响，似乎也不是介导行动受限老年人神经可塑性的主要机制因素。
