Faculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Center, Hasselt University, Agoralaan, Building A, 3590, Diepenbeek, Belgium.
BIOMED-Biomedical Research Center, Hasselt University, Diepenbeek, Belgium.
Sports Med. 2019 Oct;49(10):1529-1546. doi: 10.1007/s40279-019-01148-z.
As the prevalence of neurodegenerative diseases (such as dementia) continues to increase due to population aging, it is mandatory to understand the role of exercise for maintaining/improving brain health.
To analyse the impact of aerobic, strength and combined aerobic/strength exercise training on peripheral brain-derived neurotrophic factor (BDNF) concentrations in older adults (minimum age 60 years).
This meta-analysis adhered to PRISMA guidelines. Inclusion criteria were: (i) studies with subjects aged ≥ 60 years, (ii) completing a single exercise bout or an exercise programme, with (iii) measurements of blood BDNF in the periphery; (iv) with comparison between (a) an intervention and control group or (b) two intervention groups, or (c) pre- and post-measurements of an exercise intervention without control group. Studies with specific interest in known chronic co-morbidities or brain diseases affecting the peripheral and/or central nervous system, except for dementia, were excluded.
In general, peripheral blood BDNF concentrations increased significantly after a single aerobic/strength exercise bout (Z = 2.21, P = 0.03) as well as after an exercise programme (Z = 4.72, P < 0.001). However, when comparing the different types of exercise within these programmes, the increase in the peripheral BDNF concentrations was significant after strength training (Z = 2.94, P = 0.003) and combined aerobic/strength training (Z = 3.03, P = 0.002) but not after (low-to-moderate intense) aerobic exercise training (Z = 0.82, P = 0.41).
Based on current evidence, to increase the peripheral blood BDNF concentrations in older adults, strength training and combined aerobic/strength training is effective. More studies are needed to examine the impact of aerobic exercise training.
随着人口老龄化导致神经退行性疾病（如痴呆症）的患病率不断上升，了解运动对于维持/改善大脑健康的作用是强制性的。
分析有氧运动、力量训练和有氧/力量结合训练对老年人外周脑源性神经营养因子（BDNF）浓度的影响（最小年龄 60 岁）。
本荟萃分析遵循 PRISMA 指南。纳入标准为：（i）研究对象年龄≥60 岁，（ii）完成单次运动或运动方案，（iii）外周血 BDNF 测量；（iv）比较（a）干预组和对照组或（b）两个干预组，或（c）无对照组的运动干预前后测量。有特定兴趣研究已知影响外周和/或中枢神经系统的慢性合并症或脑部疾病的研究除外，除痴呆症外。
一般来说，单次有氧/力量运动后外周血 BDNF 浓度显著升高（Z=2.21，P=0.03），运动方案后也显著升高（Z=4.72，P<0.001）。然而，当比较这些方案中不同类型的运动时，力量训练（Z=2.94，P=0.003）和有氧/力量结合训练（Z=3.03，P=0.002）后外周 BDNF 浓度的增加具有统计学意义，但（低至中等强度）有氧运动训练后则不然（Z=0.82，P=0.41）。
基于现有证据，为了增加老年人外周血 BDNF 浓度，力量训练和有氧/力量结合训练是有效的。需要更多的研究来检查有氧运动训练的影响。
