Safii Syarida H, Tompkins Geoffrey R, Duncan Warwick J
Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin 9016, New Zealand; Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin 9016, New Zealand.
Int J Dent. 2017;2017:9874535. doi: 10.1155/2017/9874535. Epub 2017 Mar 14.
. Topical application of manuka honey is effective in the treatment of burns and soft-tissue infections. The aim of this study was to assess the antibacterial activity of manuka honey against plaque-associated bacteria in vitro in order to evaluate the potential application as an adjunct to periodontal treatment. . The minimum bacteriostatic and bactericidal concentrations (MIC and MBC) of manuka honey were compared to those of white clover honey against a variety of plaque-associated bacteria, at the natural and neutral pH. Dissolved calcium was measured following incubation of honeys with hydroxyapatite (HA) beads to assess their potential to demineralise oral hard tissues. . Both honeys inhibited most tested oral bacteria at similar MIC/MBC, but was comparatively resistant. The honeys at pH neutral had little effect on antimicrobial activity. Incubation of HA beads in honey solutions resulted in pH-dependent calcium dissolution, and inoculation with promoted further demineralisation by both types of honey. . Manuka honey is antimicrobial towards representative oral bacteria. However, the relative resistance of in association with the high concentrations of fermentable carbohydrates in honey and the direct demineralising effect at natural pH mitigate against the application of honey as an adjunct in the treatment of periodontal disease.
麦卢卡蜂蜜局部应用对烧伤和软组织感染的治疗有效。本研究的目的是评估麦卢卡蜂蜜在体外对与牙菌斑相关细菌的抗菌活性，以评估其作为牙周治疗辅助手段的潜在应用。将麦卢卡蜂蜜与白三叶草蜂蜜针对多种与牙菌斑相关细菌在自然和中性pH值下的最小抑菌浓度和最小杀菌浓度（MIC和MBC）进行比较。在蜂蜜与羟基磷灰石（HA）珠孵育后测量溶解钙，以评估它们使口腔硬组织脱矿的潜力。两种蜂蜜在相似的MIC/MBC下均抑制了大多数测试的口腔细菌，但[细菌名称未给出]相对耐药。中性pH值的蜂蜜对抗菌活性影响很小。HA珠在蜂蜜溶液中的孵育导致pH依赖性钙溶解，接种[细菌名称未给出]会促进两种蜂蜜进一步脱矿。麦卢卡蜂蜜对代表性口腔细菌具有抗菌作用。然而，[细菌名称未给出]的相对耐药性，以及蜂蜜中高浓度可发酵碳水化合物和自然pH值下的直接脱矿作用不利于将蜂蜜用作牙周疾病治疗的辅助手段。
