Bovine serum albumin-glutaraldehyde (BioGlue) tissue adhesive standard renorrhaphy following renal mass enucleation: a retrospective comparison.

BACKGROUND

To present the operative and post-operative comparison between patients who underwent tumor-bed closure with sutures compared with bovine serum albumin-glutaraldehyde (BioGlue) tissue sealant only.

METHODS

We retrospectively analyzed data from our ongoing database of 507 eligible patients who underwent open NSS nephron-sparing surgery in our department between January 1995 and May 2014. Patients had tumor-bed closure with sealant adhesive (255 patients) or standard suture technique (252 patients). Demographic, clinical and perioperative data were compared between the two groups, by Chi-square test or by Fisher-Irwin exact test for categorical variables, and by test for differences in means or by Wilcoxon rank sum test for continuous variables. A multivariate analysis was also done.

RESULTS

Patients' baseline characteristics showed similar distribution of the analyzed parameters among both groups, with few differences: younger age in the sealant group (65.4 68.4 years, = 0.01) and slightly larger mass size in the suture group (4.0 3.9 cm, = 0.03). Ischemia time was significantly shorter in the sealant group (21.8 27.0 minutes, = 0001). Blood loss and transfusion rate (0.8% 11.9%, = 0.0001) were significantly less in the sealant group. A multivariate analysis showed date of surgery and blood loss as the major parameters affecting transfusion rate.

CONCLUSIONS

Closing the tumor bed with BioGlue tissue adhesive is feasible, safe, can shorten ischemia time and potentially reduce transfusion rate.