Wang Hao, Robinson Richard D, Phillips Jessica L, Ryon Andrew, Simpson Scott, Ford Jonathan R, Umejiego Johnbosco, Duane Therese M, Putty Bradley, Zenarosa Nestor R
Department of Emergency Medicine, Integrative Emergency Services Physician Group, John Peter Smith Health Network, 1500 S. Main St., Fort Worth, TX 76104, USA.
Research Institute, John Peter Smith Health Network, 1500 S. Main St., Fort Worth, TX 76104, USA.
J Clin Med Res. 2017 May;9(5):433-438. doi: 10.14740/jocmr3005w. Epub 2017 Apr 1.
Thromboelastography (TEG) has been utilized for the guidance of blood component therapy (BCT). We aimed to investigate the association between emergent TEG-guided BCT and clinical outcomes in patients with traumatic abdominal solid organ (liver and/or spleen) injuries.
A single center retrospective study of patients who sustained traumatic liver and/or spleen injuries receiving emergent BCT was conducted. TEG was ordered in all these patients. Patient demographics, general injury information, outcomes, BCT, and TEG parameters were analyzed and compared in patients receiving TEG-guided BCT versus those without.
A total of 166 patients were enrolled, of whom 52% (86/166) received TEG-guided BCT. A mortality of 12% was noted among patients with TEG-guided BCT when compared with 19% of mortality in patients with non-TEG-guided BCT (P > 0.05). An average of 4 units of packed red blood cell (PRBC) was received in patients with TEG-guided BCT when compared to an average of 9 units of PRBC received in non-TEG-guided BCT patients (P < 0.01). A longer hospital length of stay (LOS, 19 ± 16 days) was found among non-TEG-guided BCT patients when compared to the TEG-guided BCT group (14 ± 12 days, P < 0.05). TEG-guided BCT showed as an independent factor associated with hospital LOS after other variables were adjusted (coefficiency: 5.44, 95% confidence interval: 0.69 - 10.18).
Traumatic abdominal solid organ injury patients receiving blood transfusions might benefit from TEG-guided BCT as indicated by less blood products needed and less hospitalization stay among the cohort.
血栓弹力图(TEG)已用于指导血液成分治疗(BCT)。我们旨在研究创伤性腹部实体器官(肝脏和/或脾脏)损伤患者中急诊TEG指导下的BCT与临床结局之间的关联。
对遭受创伤性肝脏和/或脾脏损伤并接受急诊BCT的患者进行单中心回顾性研究。所有这些患者均进行了TEG检查。分析并比较接受TEG指导的BCT患者与未接受TEG指导的BCT患者的人口统计学资料、一般损伤信息、结局、BCT及TEG参数。
共纳入166例患者,其中52%(86/166)接受了TEG指导的BCT。接受TEG指导的BCT患者的死亡率为12%,而非TEG指导的BCT患者的死亡率为19%(P>0.05)。接受TEG指导的BCT患者平均接受4单位浓缩红细胞(PRBC),而非TEG指导的BCT患者平均接受9单位PRBC(P<0.01)。与TEG指导的BCT组(14±12天)相比,非TEG指导的BCT患者住院时间更长(LOS,19±16天,P<0.05)。在调整其他变量后,TEG指导的BCT显示为与住院LOS相关的独立因素(系数:5.44,95%置信区间:0.69-至10.18)。
创伤性腹部实体器官损伤输血患者可能从TEG指导的BCT中获益,队列研究表明所需血液制品更少且住院时间更短。