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本文引用的文献

1
Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding.采用血栓弹力图(TEG)或血栓弹力测定法(ROTEM)监测成人或儿童出血患者的止血治疗效果并与常规治疗进行比较。
Cochrane Database Syst Rev. 2016 Aug 22;2016(8):CD007871. doi: 10.1002/14651858.CD007871.pub3.
2
Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study.通过旋转血栓弹力图检测急性创伤性凝血病和大量输血需求:一项国际前瞻性验证研究。
Crit Care. 2015 Mar 23;19(1):97. doi: 10.1186/s13054-015-0823-y.
3
Damage-control resuscitation increases successful nonoperative management rates and survival after severe blunt liver injury.损伤控制复苏可提高严重钝性肝损伤后的非手术治疗成功率及生存率。
J Trauma Acute Care Surg. 2015 Feb;78(2):336-41. doi: 10.1097/TA.0000000000000514.
4
Thromboelastography predictive of death in trauma patients.血栓弹力图可预测创伤患者的死亡情况。
Orthop Surg. 2015 Feb;7(1):26-30. doi: 10.1111/os.12158.
5
Critical care issues in solid organ injury: Review and experience in a tertiary trauma center.实体器官损伤中的重症监护问题:三级创伤中心的综述与经验
Saudi J Anaesth. 2014 Nov;8(Suppl 1):S29-35. doi: 10.4103/1658-354X.144065.
6
Defining early trauma-induced coagulopathy using thromboelastography.使用血栓弹力图定义早期创伤性凝血病。
Am Surg. 2014 Oct;80(10):994-8.
7
Hemostasis, coagulation abnormalities, and liver disease.止血、凝血异常与肝脏疾病。
Crit Care Nurs Clin North Am. 2013 Dec;25(4):435-46, v. doi: 10.1016/j.ccell.2013.09.001. Epub 2013 Oct 20.
8
Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets.在采用输血套餐和早期血栓弹力图指导的止血复苏治疗(使用血浆和血小板)的一级创伤中心,创伤患者的出血相关死亡率较低。
Transfusion. 2013 Dec;53(12):3088-99. doi: 10.1111/trf.12214. Epub 2013 Apr 25.
9
TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients.TEG 指导复苏优于标准化 MTP 复苏在大量输血穿透性创伤患者中。
J Trauma Acute Care Surg. 2013 Feb;74(2):378-85; discussion 385-6. doi: 10.1097/TA.0b013e31827e20e0.
10
Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients.急诊床旁血栓弹力图检测可替代常规凝血检测:1974 例连续创伤患者的应用经验。
Ann Surg. 2012 Sep;256(3):476-86. doi: 10.1097/SLA.0b013e3182658180.

创伤性腹部实性器官损伤患者可能从血栓弹力图引导的血液成分治疗中获益。

Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy.

作者信息

Wang Hao, Robinson Richard D, Phillips Jessica L, Ryon Andrew, Simpson Scott, Ford Jonathan R, Umejiego Johnbosco, Duane Therese M, Putty Bradley, Zenarosa Nestor R

机构信息

Department of Emergency Medicine, Integrative Emergency Services Physician Group, John Peter Smith Health Network, 1500 S. Main St., Fort Worth, TX 76104, USA.

Research Institute, John Peter Smith Health Network, 1500 S. Main St., Fort Worth, TX 76104, USA.

出版信息

J Clin Med Res. 2017 May;9(5):433-438. doi: 10.14740/jocmr3005w. Epub 2017 Apr 1.

DOI:10.14740/jocmr3005w
PMID:28392864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5380177/
Abstract

BACKGROUND

Thromboelastography (TEG) has been utilized for the guidance of blood component therapy (BCT). We aimed to investigate the association between emergent TEG-guided BCT and clinical outcomes in patients with traumatic abdominal solid organ (liver and/or spleen) injuries.

METHODS

A single center retrospective study of patients who sustained traumatic liver and/or spleen injuries receiving emergent BCT was conducted. TEG was ordered in all these patients. Patient demographics, general injury information, outcomes, BCT, and TEG parameters were analyzed and compared in patients receiving TEG-guided BCT versus those without.

RESULTS

A total of 166 patients were enrolled, of whom 52% (86/166) received TEG-guided BCT. A mortality of 12% was noted among patients with TEG-guided BCT when compared with 19% of mortality in patients with non-TEG-guided BCT (P > 0.05). An average of 4 units of packed red blood cell (PRBC) was received in patients with TEG-guided BCT when compared to an average of 9 units of PRBC received in non-TEG-guided BCT patients (P < 0.01). A longer hospital length of stay (LOS, 19 ± 16 days) was found among non-TEG-guided BCT patients when compared to the TEG-guided BCT group (14 ± 12 days, P < 0.05). TEG-guided BCT showed as an independent factor associated with hospital LOS after other variables were adjusted (coefficiency: 5.44, 95% confidence interval: 0.69 - 10.18).

CONCLUSIONS

Traumatic abdominal solid organ injury patients receiving blood transfusions might benefit from TEG-guided BCT as indicated by less blood products needed and less hospitalization stay among the cohort.

摘要

背景

血栓弹力图(TEG)已用于指导血液成分治疗(BCT)。我们旨在研究创伤性腹部实体器官(肝脏和/或脾脏)损伤患者中急诊TEG指导下的BCT与临床结局之间的关联。

方法

对遭受创伤性肝脏和/或脾脏损伤并接受急诊BCT的患者进行单中心回顾性研究。所有这些患者均进行了TEG检查。分析并比较接受TEG指导的BCT患者与未接受TEG指导的BCT患者的人口统计学资料、一般损伤信息、结局、BCT及TEG参数。

结果

共纳入166例患者,其中52%(86/166)接受了TEG指导的BCT。接受TEG指导的BCT患者的死亡率为12%,而非TEG指导的BCT患者的死亡率为19%(P>0.05)。接受TEG指导的BCT患者平均接受4单位浓缩红细胞(PRBC),而非TEG指导的BCT患者平均接受9单位PRBC(P<0.01)。与TEG指导的BCT组(14±12天)相比,非TEG指导的BCT患者住院时间更长(LOS,19±16天,P<0.05)。在调整其他变量后,TEG指导的BCT显示为与住院LOS相关的独立因素(系数:5.44,95%置信区间:0.69-至10.18)。

结论

创伤性腹部实体器官损伤输血患者可能从TEG指导的BCT中获益,队列研究表明所需血液制品更少且住院时间更短。