眼部黑色素瘤和正常脉络膜中的视黄酸结合
Retinoic binding in melanomas of the eye and in normal choroid.
作者信息
Daxecker F, Marth C, Daxenbichler G
机构信息
Department of Ophthalmology, University of Innsbruck, Austria.
出版信息
Cancer Lett. 1988 Jul;41(1):119-22. doi: 10.1016/0304-3835(88)90063-8.
Binding proteins for retinoic acid (cellular retinoid acid binding protein, CRABP), and for vitamin A (cellular retinol binding protein, CRBP) have been demonstrated in various cell types; these binding proteins display the characteristics of receptors. In the present study CRABP and CRBP levels were measured in 9 melanomas of the choroid. CRABP was detected in 2 of the melanomas, whereas CRBP was measurable in 1 melanoma. In comparison samples of normal choroid contained CRABP and CRBP in all cases investigated.
视黄酸结合蛋白（细胞视黄酸结合蛋白，CRABP）和维生素A结合蛋白（细胞视黄醇结合蛋白，CRBP）已在多种细胞类型中得到证实；这些结合蛋白表现出受体的特征。在本研究中，检测了9例脉络膜黑色素瘤中的CRABP和CRBP水平。在2例黑色素瘤中检测到CRABP，而在1例黑色素瘤中可检测到CRBP。相比之下，在所有研究的正常脉络膜样本中均含有CRABP和CRBP。
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