Khan Talal W, Yacoub Abdulraheem
Department of Anesthesiology and Pain Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Case Rep Anesthesiol. 2017;2017:6467090. doi: 10.1155/2017/6467090. Epub 2017 Mar 14.
Desmopressin (DDAVP), a synthetic analog of vasopressin, has been used in patients with von Willebrand disease (VWD), mild hemophilia A, and platelet dysfunction to reduce the risk of bleeding associated with surgical and interventional procedures. We report the case of a patient with VWD presenting with a bulging disc and radicular pain that underwent transforaminal epidural steroid injections. Her course was complicated with the interval development of headaches and dizziness symptomatic of moderate hyponatremia, likely due to excessive fluid intake. This report highlights a relatively rare side effect of DDAVP when used for prophylaxis in patients with VWD and reinforces the need for vigilance in these patients.
去氨加压素（DDAVP），一种血管加压素的合成类似物，已被用于治疗血管性血友病（VWD）、轻度甲型血友病和血小板功能障碍的患者，以降低与手术和介入操作相关的出血风险。我们报告了一例患有VWD的患者，该患者出现椎间盘突出和神经根性疼痛，并接受了经椎间孔硬膜外类固醇注射。她的病程因出现中度低钠血症症状的头痛和头晕而变得复杂，这可能是由于液体摄入过多所致。本报告强调了DDAVP在用于VWD患者预防时相对罕见的副作用，并强化了对这些患者保持警惕的必要性。
