Hamilton J W, Wagner J, Burdick B B, Bass P
Department of Medicine, University of Wisconsin, Madison.
Dig Dis Sci. 1988 Aug;33(8):993-8. doi: 10.1007/BF01535996.
We studied a bulk laxative containing methylcellulose in a group of normal subjects as well as in a group of chronically constipated individuals. The initial study in normal subjects was performed to show that the compound could increase fecal weight without significant side effects. Fifty healthy subjects were studied. Methylcellulose in daily doses of 4 g demonstrated a statistically significant increase in fecal frequency, fecal water, and fecal solids. In the second phase, we studied a group of 59 chronically constipated individuals treated with daily doses of the laxative containing either 1, 2, or 4 g of methylcellulose or 3.4 g psyllium. All of these doses resulted in statistically significant increases in stool frequency, water content, and fecal solids. There was no increase in individual stool weight from any of the laxative doses. Methylcellulose, in a daily dose as low as 1 g, is an effective laxative.
我们在一组正常受试者以及一组慢性便秘患者中研究了一种含有甲基纤维素的容积性泻药。在正常受试者中进行的初始研究旨在表明该化合物可增加粪便重量且无明显副作用。研究了50名健康受试者。每日服用4克甲基纤维素可使粪便频率、粪便水分和粪便固体量在统计学上显著增加。在第二阶段，我们研究了一组59名慢性便秘患者，他们每日服用含有1克、2克或4克甲基纤维素或3.4克车前草的泻药。所有这些剂量均使大便频率、水分含量和粪便固体量在统计学上显著增加。任何一种泻药剂量均未使个体粪便重量增加。甲基纤维素，每日剂量低至1克，就是一种有效的泻药。
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