丙泊酚诱导的急性胰腺炎。
Propofol-induced acute pancreatitis.
作者信息
Csomor J, Murínová I, Broulíková K, Kučerka O, Sedloň P, Jarošek J, Urbánek P, Zavoral M
机构信息
Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.
Department of Clinical Pharmacy, Military University Hospital Prague, Prague, Czech Republic.
出版信息
J Clin Pharm Ther. 2017 Aug;42(4):495-498. doi: 10.1111/jcpt.12524. Epub 2017 Apr 10.
WHAT IS KNOWN AND OBJECTIVE
Drug-induced acute pancreatitis comprises only 0.5%-2% of all cases of acute pancreatitis. Propofol is a potentially dangerous drug that can cause acute pancreatitis, but this complication is extremely rare.
CASE SUMMARY
A 57-year-old patient developed acute pancreatitis after a planned thyroidectomy. As the common causes of acute pancreatitis were excluded, we believe that the pancreatitis was drug-induced, in this case by a single dose of propofol administered to the patient during the surgery.
WHAT IS NEW AND CONCLUSION
We present a rare case of propofol-induced acute necrotising pancreatitis, which is to the best of our knowledge the first fatal case reported in an adult patient.
已知信息与目的
药物性急性胰腺炎仅占所有急性胰腺炎病例的0.5%-2%。丙泊酚是一种可能引发急性胰腺炎的危险药物，但这种并发症极为罕见。
病例摘要
一名57岁患者在计划进行的甲状腺切除术后发生急性胰腺炎。由于排除了急性胰腺炎的常见病因，我们认为该胰腺炎是药物所致，在此病例中是手术期间给患者单次使用丙泊酚引起的。
新发现与结论
我们报告了一例罕见的丙泊酚诱导的急性坏死性胰腺炎病例，据我们所知，这是首例在成年患者中报道的致命病例。
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