Gottschling Sven, Larsen Reinhard, Meyer Sascha, Graf Norbert, Reinhard Harald
Department of Pediatric Hematology and Oncology, Universtiy Children's Hospital, Kirrbergestr, Homburg/Saar, Germany.
Paediatr Anaesth. 2005 Nov;15(11):1006-8. doi: 10.1111/j.1460-9592.2004.01562.x.
The incidence of a drug-induced pancreatitis is rare and so far more than 85 different drugs have been reported to have induced pancreatitis. Some case reports consider a relationship between propofol and acute pancreatitis. However, in these cases a number of different drugs were coadministered, thus preventing a clear causal link being established. We report a case of a drug-induced acute pancreatitis that was most likely triggered by a single dosage of propofol. It occurred in a young girl who underwent elective magnetic resonance imaging. She developed pancreatitis within hours after exposure to propofol. Other possible triggers, e.g. gallstones or infection were ruled out. Physicians should consider pancreatitis as a potentially life-threatening adverse event associated with propofol sedation, which is nowadays extensively used.
药物性胰腺炎的发病率很低，迄今为止，已有超过85种不同药物被报告可诱发胰腺炎。一些病例报告认为丙泊酚与急性胰腺炎之间存在关联。然而，在这些病例中，同时使用了多种不同药物，因此无法明确建立因果关系。我们报告一例药物性急性胰腺炎病例，极有可能是由单次剂量的丙泊酚引发的。该病例发生在一名接受择期磁共振成像检查的年轻女孩身上。她在接触丙泊酚数小时内就患上了胰腺炎。其他可能的诱因，如胆结石或感染，均被排除。医生应将胰腺炎视为与丙泊酚镇静相关的一种潜在危及生命的不良事件，而丙泊酚如今被广泛使用。
