环（组氨酸-脯氨酸）浓度。高血糖大鼠脑纹状体的变化。

Cyclo(His-Pro) concentration. Changes in brain striatum of hyperglycemic rat.

作者信息

Mori M, Iriuchijima T, Yamada M

机构信息

First Department of Internal Medicine, Gunma University, School of Medicine, Maebashi, Japan.

出版信息

Diabetes. 1988 Aug;37(8):1120-2. doi: 10.2337/diab.37.8.1120.

DOI:10.2337/diab.37.8.1120

PMID:2839388

Abstract

We scrutinized whether the hyperglycemic status changed the concentration of prototype neuropeptides cyclo(His-Pro) and thyrotropin-releasing hormone (TRH) in the rat brain. Streptozocin-induced hyperglycemia caused a significant increase in cyclo(His-Pro) concentration in the striatum but not in the other brain regions, whereas TRH concentration in any brain region did not differ between control and hyperglycemic groups. Insulin injection normalized blood glucose level and prevented an increase in cyclo(His-Pro) concentration after hyperglycemia. These data indicate that hyperglycemia causes a profound alteration in cyclo(His-Pro) concentration in the rat brain striatum.

摘要

我们研究了高血糖状态是否会改变大鼠脑中原型神经肽环（组氨酸-脯氨酸）和促甲状腺激素释放激素（TRH）的浓度。链脲佐菌素诱导的高血糖导致纹状体中环（组氨酸-脯氨酸）浓度显著升高，但其他脑区未出现这种情况，而对照组和高血糖组之间任何脑区的TRH浓度均无差异。注射胰岛素可使血糖水平恢复正常，并防止高血糖后环（组氨酸-脯氨酸）浓度升高。这些数据表明，高血糖会导致大鼠脑纹状体中环（组氨酸-脯氨酸）浓度发生深刻变化。