蛋白质-能量营养不良会改变新生大鼠大脑中的促甲状腺激素释放激素和环（组氨酸-脯氨酸）。

Protein-energy malnutrition alters brain thyrotropin-releasing hormone and cyclo (His-Pro) in the neonatal rat.

作者信息

Mori M, Prasad C, Wilber J F, Nakamoto T

出版信息

Neurosci Lett. 1983 Dec 30;43(2-3):241-4. doi: 10.1016/0304-3940(83)90195-7.

Abstract

To evaluate effects of protein-energy malnutrition on the brain neuropeptides thyrotropin-releasing hormone (TRH) and cyclo (His-Pro) in the cerebellum and the remainder brain, we studied neonatal rats in the lactational period. Protein-energy malnutrition caused an increase in cyclo (His-Pro) concentrations, but not in TRH concentrations, in the neonatal cerebellum. In the remainder brain, a reduction in cyclo (His-Pro) concentrations occurred with an increase in TRH concentrations. These data indicate that protein-energy malnutrition affects both brain TRH and cyclo (His-Pro) in the neonatal rats during lactation.

摘要

为评估蛋白质能量营养不良对新生大鼠哺乳期小脑及其他脑区神经肽促甲状腺激素释放激素（TRH）和环（组氨酸-脯氨酸）的影响，我们进行了相关研究。蛋白质能量营养不良导致新生大鼠小脑中环（组氨酸-脯氨酸）浓度升高，但TRH浓度未升高。在其他脑区，环（组氨酸-脯氨酸）浓度降低，而TRH浓度升高。这些数据表明，蛋白质能量营养不良会影响新生大鼠哺乳期大脑中的TRH和环（组氨酸-脯氨酸）。