Ciortea Răzvan, Malutan Andrei M, Angheluta Lenuta M, Bucuri Carmen E, Rada Maria P, Mihu Dan
Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Rev Med Chil. 2016 Dec;144(12):1577-1583. doi: 10.4067/S0034-98872016001200009.
The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance.
To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer.
Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured.
GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01).
GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.
脂肪细胞中内质网（ER）应激的存在支持了肥胖与子宫内膜癌之间的关联。葡萄糖调节蛋白78（GRP78）是内质网应激的标志物。由于其主要的抗凋亡作用，该蛋白是内质网应激的核心调节因子。它在肿瘤发生、发展和化疗耐药中起重要作用。
探讨男性型肥胖和女性型肥胖、血浆GRP78水平与子宫内膜癌之间的关联。
研究了44例年龄为72±6岁的子宫内膜癌患者和44例年龄为55±9岁的健康女性。通过双能X线吸收法测定男性型和女性型脂肪分布，并测量血浆GRP78水平。
与对照组相比，子宫内膜癌患者的血浆GRP78水平显著更高。男性型脂肪分布与血浆GRP78水平呈正相关（p<0.01）。女性型脂肪与血浆GRP78水平呈负相关（p<0.01）。
GRP78水平与脂肪组织分布相关，且在子宫内膜癌患者中更高。
