神经肿瘤腹侧抗原1（NOVA1）：在神经疾病和癌症中的意义。
Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers.
作者信息
Xin Yu, Li Zheng, Zheng Heyi, Ho Jeffery, Chan Matthew T V, Wu William K K
机构信息
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
出版信息
Cell Prolif. 2017 Aug;50(4). doi: 10.1111/cpr.12348. Epub 2017 Apr 10.
Abstract
Neuro-oncological ventral antigen 1 (NOVA1) is a RNA-binding protein that interacts with RNA containing repeats of the YCAY sequence. This protein is a brain-specific splicing factor regulating neuronal alternative splicing. It has been increasingly recognized as an important contributor to neurological disorders and carcinogenesis. In this review, we summarize the biological functions and pathological roles of NOVA1. The clinical implications of NOVA1 will also be discussed.
摘要
神经肿瘤腹侧抗原1（NOVA1）是一种RNA结合蛋白，它与含有YCAY序列重复的RNA相互作用。这种蛋白质是一种调节神经元可变剪接的脑特异性剪接因子。它已越来越被认为是神经疾病和致癌作用的重要促成因素。在本综述中，我们总结了NOVA1的生物学功能和病理作用。还将讨论NOVA1的临床意义。
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本文引用的文献
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