使用氧化石墨烯纳米颗粒增强人胎儿神经干细胞的自我更新并加速其分化
Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles.
作者信息
Kim Jin, Yang Kisuk, Lee Jong Seung, Hwang Yong Hwa, Park Hyun-Ji, Park Kook In, Lee Dong Yun, Cho Seung-Woo
机构信息
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science and Technology (INST), Hanyang University, Seoul, 04763, Republic of Korea.
出版信息
Macromol Biosci. 2017 Aug;17(8). doi: 10.1002/mabi.201600540. Epub 2017 Apr 10.
Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis.
氧化石墨烯（GO）因其独特的生物物理和电学性质以及出色的生物相容性，在生物工程领域受到越来越多的关注。据报道，氧化石墨烯纳米颗粒（GO-NPs）可用于调控人类胎儿神经干细胞（hfNSCs）的自我更新和分化。在神经球形成过程中添加到hfNSC培养物中的GO-NPs可显著促进神经球中细胞间和细胞与基质间的相互作用。因此，与未处理的细胞相比，经GO-NP处理的hfNSCs表现出更强的自我更新能力和更快的分化速度，这表明GO在开发用于神经发生的干细胞疗法中具有实用性。
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