Miyoshi S, Minami Y, Kawata S, Imai Y, Saitoh R, Noda S, Tamura S, Tarui S
Second Department of Internal Medicine, Osaka University Medical School, Japan.
J Hepatol. 1988 Jun;6(3):332-6. doi: 10.1016/s0168-8278(88)80050-3.
To clarify the influence of transcatheter arterial embolization (TAE) on hepatic function, the maximal removal rate of indocyanine green (ICG-Rmax), which represents the hepatic functional reserve, and the plasma disappearance rate of indocyanine green (k-ICG) were measured serially before and after 15 TAE procedures performed on 13 hepatocellular carcinoma (HCC) patients with underlying hepatic diseases. Compared to the values before TAE, ICG-Rmax values did not change or gradually decreased during 4 weeks in seven of the 13 patients but markedly decreased in the remaining six by as much as 50% during the first week. k-ICG values remained almost unchanged at any time after TAE. Albumin and prothrombin time were serially measured before and after 24 TAE procedures performed on 21 HCC patients with underlying hepatic diseases in whom no plasma products had been used for therapy. Albumin decreased by up to 75% in one of the 21 patients during the first week but did not change or gradually decreased in 20 of the 21 patients. Prothrombin time showed no obvious changes. This study showed that prominent changes occurred in ICG-Rmax, i.e., in the hepatic functional reserve, after TAE.
为阐明经导管动脉栓塞术（TAE）对肝功能的影响，对13例患有基础肝脏疾病的肝细胞癌（HCC）患者进行了15次TAE手术，分别在术前和术后连续测量了代表肝功能储备的靛氰绿最大清除率（ICG-Rmax）以及靛氰绿血浆消失率（k-ICG）。与TAE术前的值相比，13例患者中有7例在4周内ICG-Rmax值未改变或逐渐下降，但其余6例在第一周内显著下降多达50%。TAE术后任何时间k-ICG值几乎保持不变。对21例患有基础肝脏疾病且未使用血浆制品进行治疗的HCC患者进行了24次TAE手术，分别在术前和术后连续测量白蛋白和凝血酶原时间。21例患者中有1例在第一周内白蛋白下降多达75%，但21例患者中有20例未改变或逐渐下降。凝血酶原时间无明显变化。本研究表明，TAE术后ICG-Rmax即肝功能储备发生了显著变化。
