Lalaouna David, Massé Eric
Department of Biochemistry, RNA Group, Université de Sherbrooke, Sherbrooke, QC, Canada.
EMBO J. 2017 May 2;36(9):1120-1122. doi: 10.15252/embj.201797019. Epub 2017 Apr 10.
Transcription and translation are two complex mechanisms that are tightly coupled in prokaryotic cells. Even before the completion of transcription, ribosomes attach to the nascent mRNA and initiate protein synthesis. Remarkably, recent publications have indicated an association between translation and decay of certain mRNAs. In this issue of , Leroy (2017) depicts a fascinating mechanism of mRNA degradation, which involves the ribosome-associated ribonuclease Rae1 in In a translation-dependent manner, Rae1 binds the ribosomal aminoacylation (A)-site and cleaves between specific codons of the targeted mRNA.
转录和翻译是原核细胞中紧密偶联的两个复杂机制。甚至在转录完成之前,核糖体就会附着到新生的mRNA上并启动蛋白质合成。值得注意的是,最近的出版物表明某些mRNA的翻译与降解之间存在关联。在本期杂志中,勒罗伊(2017年)描述了一种迷人的mRNA降解机制,该机制涉及核糖体相关的核糖核酸酶Rae1。以翻译依赖的方式,Rae1结合核糖体氨酰化(A)位点并在目标mRNA的特定密码子之间切割。