Passali Desiderio, Santantonio Mariaconsiglia, Passali Giulio Cesare
University of Siena ENT Clinic, Former IFOS President, Siena, Italy.
Complex Operational Unit of Ear, Nose and Throat Sciences, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, 00168, Italy.
Sleep Breath. 2025 May 19;29(3):188. doi: 10.1007/s11325-025-03361-9.
This study focused on evaluating the clinical significance of oxidative stress biomarkers in patients with OSAS. We investigated how nasal respiratory obstruction in OSAS patients might affect the oxidative balance.
Sixty patients were divided into three groups (n = 20 each): severe OSAS (AHI > 30), snoring with AHI < 15 (mild OSAS), and nasal respiratory impairment with AHI < 5. All subjects underwent ENT examination, rhinomanometry, polysomnography, and oxidative stress biomarker analysis.
From the measurements of biomarkers associated with oxidative stress, specifically NPBI (non-protein bound iron), AOPP (Advanced Oxidation Protein Products), Isoprostanes (both plasmatic ad urinary), and Thiols, no statistically significant differences emerged among the subjects belonging to the three groups (patients with OSAS, subjects with snoring and AHI < 15, subjects with nasal respiratory impairment only and AHI < 5).
The presence of oxidative stress markers in patients with nasal obstruction, even in the absence of severe OSAS, highlights the potential role of nasal airflow limitation as a contributing factor in the pathogenesis of sleep-disordered breathing. A better understanding of the oxidative stress profile in these conditions might contribute to refining diagnostic and therapeutic approaches, and potentially reduce the reliance on polysomnography in selected cases.
本研究聚焦于评估阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者氧化应激生物标志物的临床意义。我们探究了OSAS患者的鼻呼吸阻塞如何影响氧化平衡。
60名患者被分为三组（每组n = 20）：重度OSAS（呼吸暂停低通气指数[AHI] > 30）、打鼾且AHI < 15（轻度OSAS）以及鼻呼吸障碍且AHI < 5。所有受试者均接受耳鼻喉检查、鼻阻力测量、多导睡眠监测以及氧化应激生物标志物分析。
从与氧化应激相关的生物标志物测量结果来看，具体包括非蛋白结合铁（NPBI）、晚期氧化蛋白产物（AOPP）、异前列腺素（血浆和尿液中的）以及硫醇，三组受试者（OSAS患者、打鼾且AHI < 15的受试者、仅存在鼻呼吸障碍且AHI < 5的受试者）之间未出现统计学上的显著差异。
即使在没有重度OSAS的情况下，鼻塞患者中氧化应激标志物的存在凸显了鼻气流受限在睡眠呼吸障碍发病机制中作为一个促成因素的潜在作用。更好地了解这些情况下的氧化应激特征可能有助于完善诊断和治疗方法，并有可能在特定病例中减少对多导睡眠监测的依赖。
