Amer Radgonde, Alsughayyar Walaa, Almeida Diego
Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.
Graefes Arch Clin Exp Ophthalmol. 2017 Jul;255(7):1423-1432. doi: 10.1007/s00417-017-3667-0. Epub 2017 Apr 10.
To analyze the pattern and causes of visual loss in patients with Behçet's uveitis and to report on the short-term outcome at 6 months and at last follow-up visit. Also, to analyze the pattern of visual acuity changes in eyes with and without macular involvement at the specified time points.
This is a retrospective cohort study of a single-center in an academic practice. Fifty-three patients with Behçet's uveitis evaluated between 2004 and 2014 were included. Data on patients diagnosed with Behçet's uveitis were entered retrospectively into a database and analyzed.
Included were 93 eyes with Behçet's uveitis involving the posterior segment. Frequencies of ≤20/50 and of ≤20/200 VA at presentation were 23.7% and 37.6%, respectively. Retinitis, macular inflammatory infiltrate, and dense vitritis were significantly associated with worse vision. Eyes with macular atrophy and macular inflammatory infiltrate sustained the worst logMAR VA at presentation (1.87 and 1.73, respectively) compared to eyes with cystoid macular edema and epiretinal membrane (0.76 and 0.63, respectively). Eyes with no macular involvement had the best VA at presentation. Mean difference in logMAR VA between presentation and the specified time points was greatest for eyes with macular inflammatory infiltrate.
Behçet's disease affected mostly young males with a male-to-female ratio of 4.8:1. Panuveitis and posterior uveitis were the predominant forms and they were intrinsically associated with sight-threatening potential and breadth of ocular complications for which aggressive immunosuppressive therapy was essential.
分析白塞氏葡萄膜炎患者视力丧失的模式及原因，并报告6个月时和末次随访时的短期结局。同时，分析在特定时间点有或无黄斑受累的眼睛的视力变化模式。
这是一项在学术机构单中心进行的回顾性队列研究。纳入了2004年至2014年间评估的53例白塞氏葡萄膜炎患者。将诊断为白塞氏葡萄膜炎患者的数据回顾性录入数据库并进行分析。
纳入93只患有累及后段的白塞氏葡萄膜炎的眼睛。就诊时视力≤20/50和≤20/200的频率分别为23.7%和37.6%。视网膜炎、黄斑炎性浸润和浓密玻璃体炎与较差视力显著相关。与黄斑囊样水肿和视网膜前膜的眼睛相比（分别为0.76和0.63），黄斑萎缩和黄斑炎性浸润的眼睛在就诊时维持最差的最小分辨角对数视力（分别为1.87和1.73）。无黄斑受累的眼睛在就诊时视力最佳。黄斑炎性浸润的眼睛在就诊时与特定时间点之间最小分辨角对数视力的平均差异最大。
白塞氏病主要影响年轻男性，男女比例为4.8:1。全葡萄膜炎和后葡萄膜炎是主要形式，它们本质上与威胁视力的可能性和眼部并发症的广度相关，积极的免疫抑制治疗对此至关重要。
