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饮食在炎症性肠病中的作用。

The Role of Diet in Inflammatory Bowel Disease.

作者信息

Shivashankar Raina, Lewis James D

机构信息

Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA.

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 720 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104, USA.

出版信息

Curr Gastroenterol Rep. 2017 May;19(5):22. doi: 10.1007/s11894-017-0563-z.

Abstract

PURPOSE OF REVIEW

Diet may play both a causal and therapeutic role for inflammatory bowel disease (IBD). Physicians caring for patients with IBD are often asked to make dietary recommendations. However, there are no well-established guidelines on the use of diet as a treatment of IBD. In this review, we describe the evidence supporting diet as a potential cause for IBD, patient-perceived symptoms based on diet, current research on various diets as a treatment for IBD, and areas of future research.

RECENT FINDINGS

New studies in murine models suggest that dietary emulsifiers may trigger the gut inflammatory cascade. New studies of restriction diets in patients have shown a relationship between dietary intake, symptoms, and bowel inflammation. Until several ongoing clinical trials are completed, a reasonable approach to dietary recommendations for patients with IBD is to propose a well-balanced, healthy (low-fat, low-sugar) diet prepared from fresh ingredients, such as the Mediterranean diet, with exclusions of self-identified foods that worsen or trigger IBD-related symptoms.

摘要

综述目的

饮食可能在炎症性肠病(IBD)的病因及治疗方面均发挥作用。照料IBD患者的医生经常被要求给出饮食建议。然而,目前尚无关于饮食用于IBD治疗的确立完善的指南。在本综述中,我们描述了支持饮食作为IBD潜在病因的证据、基于饮食的患者自觉症状、目前关于各种饮食用于IBD治疗的研究以及未来研究方向。

最新发现

小鼠模型中的新研究表明,膳食乳化剂可能触发肠道炎症级联反应。针对患者的限食新研究显示了饮食摄入、症状与肠道炎症之间的关联。在若干正在进行的临床试验完成之前,针对IBD患者饮食建议的合理方法是推荐一种由新鲜食材制备的营养均衡、健康(低脂、低糖)的饮食,如地中海饮食,并排除患者自行确认的会加重或引发IBD相关症状的食物。

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