Hou Jason K, Lee Dale, Lewis James
Houston VA HSR&D Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas; Department of Medicine, Baylor College of Medicine, Houston, Texas.
Department of Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
Clin Gastroenterol Hepatol. 2014 Oct;12(10):1592-600. doi: 10.1016/j.cgh.2013.09.063. Epub 2013 Oct 6.
Patients have strong beliefs about the role of diet in the cause of inflammatory bowel disease (IBD) and in exacerbating or alleviating ongoing symptoms from IBD. The rapid increase in the incidence and prevalence of IBD in recent decades strongly suggests an environmental trigger for IBD, one of which may be dietary patterns. There are several pathways where diet may influence intestinal inflammation, such as direct dietary antigens, altering the gut microbiome, and affecting gastrointestinal permeability. However, data that altering diet can change the natural history of IBD are scarce, and evidence-based dietary guidelines for patients with IBD are lacking. Patients, therefore, seek nonmedical resources for dietary guidance, such as patient support groups and unverified sources on the Internet. The aim of this review is to identify patient-targeted dietary recommendations for IBD and to critically appraise the nutritional value of these recommendations. We review patient-targeted dietary information for IBD from structured Internet searches and popular defined diets. Patient-targeted dietary recommendations focus on food restrictions and are highly conflicting. High-quality dietary intervention studies are needed to facilitate creation of evidence-based dietary guidelines for patients with IBD.
患者对饮食在炎症性肠病(IBD)病因中所起的作用以及对IBD现有症状的加重或缓解作用有着坚定的信念。近几十年来,IBD的发病率和患病率迅速上升,这有力地表明IBD存在环境触发因素,其中之一可能是饮食模式。饮食可能通过多种途径影响肠道炎症,如直接的饮食抗原、改变肠道微生物群以及影响胃肠道通透性。然而,关于改变饮食能改变IBD自然病程的数据很少,且缺乏针对IBD患者的循证饮食指南。因此,患者会寻求非医学资源获取饮食指导,如患者支持小组和互联网上未经证实的信息来源。本综述的目的是确定针对IBD患者的饮食建议,并严格评估这些建议的营养价值。我们从结构化的互联网搜索和流行的特定饮食中回顾针对IBD患者的饮食信息。针对患者的饮食建议侧重于食物限制,且存在很大冲突。需要高质量的饮食干预研究来促进为IBD患者制定循证饮食指南。