• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

内源性小鼠乳腺肿瘤病毒除了在泌乳乳腺中表达外，还在多个器官中表达。

Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland.

作者信息

Henrard D, Ross S R

机构信息

Department of Biological Chemistry, University of Illinois School of Medicine, Chicago 60612.

出版信息

J Virol. 1988 Aug;62(8):3046-9. doi: 10.1128/JVI.62.8.3046-3049.1988.

DOI:10.1128/JVI.62.8.3046-3049.1988
PMID:2839721
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253747/
Abstract

We studied the transcription of endogenous mouse mammary tumor virus (MMTV) in transgenic and normal strains of mice of different genetic backgrounds. Although the lactating mammary gland in all strains showed the highest level of MMTV expression, detectable levels of viral RNA were also found in the lungs, kidneys, salivary glands, seminal vesicles and/or prostate gland, testes, and lymphoid tissue in mice which contain different endogenous proviruses. Transcription in transgenic mice containing the MMTV long terminal repeat linked to the simian virus 40 early region also occurred in these same organs. These results indicate that the MMTV long terminal repeat functions in several organs in addition to the lactating mammary gland.

摘要

我们研究了不同遗传背景的转基因小鼠和正常小鼠品系中内源性小鼠乳腺肿瘤病毒（MMTV）的转录情况。尽管所有品系的泌乳乳腺均显示出最高水平的MMTV表达，但在含有不同内源性前病毒的小鼠的肺、肾、唾液腺、精囊和/或前列腺、睾丸及淋巴组织中也检测到了可检测水平的病毒RNA。含有与猿猴病毒40早期区域相连的MMTV长末端重复序列的转基因小鼠在这些相同器官中也发生了转录。这些结果表明，MMTV长末端重复序列除了在泌乳乳腺中发挥作用外，还在多个器官中发挥功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c14/253747/7d9114f1cf34/jvirol00087-0530-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c14/253747/0853ad11e782/jvirol00087-0529-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c14/253747/aa0364764353/jvirol00087-0529-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c14/253747/7d9114f1cf34/jvirol00087-0530-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c14/253747/0853ad11e782/jvirol00087-0529-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c14/253747/aa0364764353/jvirol00087-0529-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c14/253747/7d9114f1cf34/jvirol00087-0530-a.jpg

相似文献

1
Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland.内源性小鼠乳腺肿瘤病毒除了在泌乳乳腺中表达外，还在多个器官中表达。
J Virol. 1988 Aug;62(8):3046-9. doi: 10.1128/JVI.62.8.3046-3049.1988.
2
A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but not lactation-dependent expression in transgenic mice.一种小鼠乳腺肿瘤病毒乳腺增强子在转基因小鼠中赋予组织特异性表达，但不依赖于泌乳。
J Virol. 1992 Dec;66(12):7529-32. doi: 10.1128/JVI.66.12.7529-7532.1992.
3
The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice.小鼠乳腺肿瘤病毒长末端重复序列指导转基因小鼠不同组织的上皮细胞和淋巴细胞中的基因表达。
J Virol. 1987 Oct;61(10):3013-9. doi: 10.1128/JVI.61.10.3013-3019.1987.
4
Mouse mammary tumor virus DNA methylation: tissue-specific variation.小鼠乳腺肿瘤病毒DNA甲基化：组织特异性变异
Virology. 1984 Jul 15;136(1):69-77. doi: 10.1016/0042-6822(84)90248-4.
5
Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice.小鼠乳腺肿瘤病毒在转基因小鼠中正确组织特异性表达的负调控
Mol Cell Biol. 1990 Nov;10(11):5822-9. doi: 10.1128/mcb.10.11.5822-5829.1990.
6
Mouse mammary tumor virus gene expression regulated in trans by Lps locus.小鼠乳腺肿瘤病毒基因表达受Lps基因座反式调控。
Virology. 1985 Nov;147(1):210-3. doi: 10.1016/0042-6822(85)90241-7.
7
Organization and expression of mouse mammary tumor virus sequences in normal and neoplastic C3Hf/HeSed mouse tissues.正常和肿瘤性C3Hf/HeSed小鼠组织中小鼠乳腺肿瘤病毒序列的组织与表达
J Virol. 1984 Nov;52(2):328-35. doi: 10.1128/JVI.52.2.328-335.1984.
8
Regulation of endogenous murine mammary tumor virus expression in C57BL mouse lactating mammary glands: transcription of functional mRNA with a block at the translational level.C57BL小鼠泌乳乳腺中内源性鼠乳腺肿瘤病毒表达的调控：功能性mRNA的转录，在翻译水平存在阻断。
J Virol. 1983 Jun;46(3):818-28. doi: 10.1128/JVI.46.3.818-828.1983.
9
A redundant nuclear protein binding site contributes to negative regulation of the mouse mammary tumor virus long terminal repeat.一个冗余的核蛋白结合位点有助于对小鼠乳腺肿瘤病毒长末端重复序列进行负调控。
J Virol. 1995 Dec;69(12):7868-76. doi: 10.1128/JVI.69.12.7868-7876.1995.
10
Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.小鼠乳腺肿瘤病毒的乳腺表达受长末端重复序列中一个新元件的调控。
J Virol. 1999 Jan;73(1):368-76. doi: 10.1128/JVI.73.1.368-376.1999.

引用本文的文献

1
Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene.由于Pds5b基因破坏导致纯合人源Her-2转基因小鼠胚胎致死
PLoS One. 2015 Sep 3;10(9):e0136817. doi: 10.1371/journal.pone.0136817. eCollection 2015.
2
Endogenous antibodies for tumor detection.用于肿瘤检测的内源性抗体。
Sci Rep. 2014 May 30;4:5088. doi: 10.1038/srep05088.
3
Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.Brms1 的普遍表达对于通过促进细胞凋亡来抑制乳腺癌转移是至关重要的。

本文引用的文献

1
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes.携带并表达MTV/ myc融合基因的转基因小鼠中的自发性乳腺腺癌。
Cell. 1984 Oct;38(3):627-37. doi: 10.1016/0092-8674(84)90257-5.
2
The chromosomal integration site determines the tissue-specific methylation of mouse mammary tumour virus proviral genes.染色体整合位点决定小鼠乳腺肿瘤病毒前病毒基因的组织特异性甲基化。
EMBO J. 1984 May;3(5):1129-35. doi: 10.1002/j.1460-2075.1984.tb01941.x.
3
Mouse mammary tumor virus: specific methylation patterns of proviral DNA in normal mouse tissues.
Clin Exp Metastasis. 2012 Apr;29(4):315-25. doi: 10.1007/s10585-012-9452-x. Epub 2012 Jan 13.
4
A 5' distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin.小鼠乳腺肿瘤病毒长末端重复序列内的一个5' 远端回文序列招募了一种乳腺特异性复合物，并且是对孕酮加催乳素协同反应所必需的。
J Mol Endocrinol. 2008 Aug;41(2):75-90. doi: 10.1677/JME-08-0027. Epub 2008 Jun 4.
5
MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells.在唾液腺腺泡细胞中，MDM2是激活的Akt1抑制细胞凋亡所必需的。
Mol Cell Biol. 2006 Dec;26(23):8840-56. doi: 10.1128/MCB.01846-05. Epub 2006 Sep 18.
6
Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.在转基因小鼠中，活化的小鼠Notch1和Notch3的过表达会阻碍乳腺发育并诱发乳腺肿瘤。
Am J Pathol. 2006 Mar;168(3):973-90. doi: 10.2353/ajpath.2006.050416.
7
CDP binding to multiple sites in the mouse mammary tumor virus long terminal repeat suppresses basal and glucocorticoid-induced transcription.CDP与小鼠乳腺肿瘤病毒长末端重复序列中的多个位点结合可抑制基础转录和糖皮质激素诱导的转录。
J Virol. 2002 Mar;76(5):2168-79. doi: 10.1128/jvi.76.5.2168-2179.2002.
8
Viruses in the mammalian male genital tract and their effects on the reproductive system.哺乳动物雄性生殖道中的病毒及其对生殖系统的影响。
Microbiol Mol Biol Rev. 2001 Jun;65(2):208-31 ; first and second pages, table of contents. doi: 10.1128/MMBR.65.2.208-231.2001.
9
Rescue of an MMTV transgene by co-integration reveals novel locus control properties of the ovine beta-lactoglobulin gene that confer locus commitment to heterogeneous tissues.通过共整合挽救MMTV转基因揭示了绵羊β-乳球蛋白基因的新基因座控制特性，这些特性赋予基因座对异质组织的定向性。
Transgenic Res. 1998 May;7(3):205-12. doi: 10.1023/a:1008893030461.
10
Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation.同源结构域蛋白CDP和SATB1相互作用：组织特异性调控的潜力。
Mol Cell Biol. 1999 Jul;19(7):4918-26. doi: 10.1128/MCB.19.7.4918.
小鼠乳腺肿瘤病毒：正常小鼠组织中前病毒DNA的特定甲基化模式
J Virol. 1984 Jan;49(1):66-71. doi: 10.1128/JVI.49.1.66-71.1984.
4
Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region.糖皮质激素受体与转录区域内及上游位点的MTV DNA发生序列特异性结合。
Cell. 1983 Dec;35(2 Pt 1):381-92. doi: 10.1016/0092-8674(83)90171-x.
5
Activation of mouse genes in transformed cells.转化细胞中小鼠基因的激活。
Cell. 1983 Sep;34(2):557-67. doi: 10.1016/0092-8674(83)90388-4.
6
Quantitative of murine mammary tumor virus-related RNA in mammary tissues of low- and high-mammary-tumor-incidence mouse strains.低乳腺肿瘤发病率和高乳腺肿瘤发病率小鼠品系乳腺组织中鼠乳腺肿瘤病毒相关RNA的定量分析
J Virol. 1981 Oct;40(1):87-95. doi: 10.1128/JVI.40.1.87-95.1981.
7
Distribution of mouse mammary tumour virus antigens in RIII mice as detected by immunofluorescence on tissue sections and by immunoassays in sera and organ extracts.通过组织切片免疫荧光以及血清和器官提取物免疫测定法检测RIII小鼠中鼠乳腺肿瘤病毒抗原的分布。
J Gen Virol. 1980 Dec;51(Pt 2):327-39. doi: 10.1099/0022-1317-51-2-327.
8
Subset of spleen lymphocytes from BALB/cCrgl mice stimulated by mouse mammary tumor virus.
Cancer Res. 1981 Mar;41(3):813-8.
9
The methylation pattern of endogenous mouse mammary tumor virus proviral genes is tissue specific and stably inherited.内源性小鼠乳腺肿瘤病毒前病毒基因的甲基化模式具有组织特异性且能稳定遗传。
Virology. 1984 Oct 30;138(2):212-24. doi: 10.1016/0042-6822(84)90346-5.
10
Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains.高肿瘤发生率和低肿瘤发生率小鼠品系组织中小鼠乳腺肿瘤病毒基因的转录
J Mol Biol. 1973 Oct 5;79(4):663-79. doi: 10.1016/0022-2836(73)90070-3.