Forbat E, Ali F R, Al-Niaimi F
King Edward VII Hospital, London, UK.
Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
Clin Exp Dermatol. 2017 Jun;42(4):374-380. doi: 10.1111/ced.13058. Epub 2017 Apr 10.
Acne scars are present in 95% of patients with acne, and can cause profound psychosocial morbidity. Fillers are commonly used for facial soft tissue augmentation, and there is increasing interest in their use for the treatment of acne scars, particularly for the atrophic subtype. We review the evidence for the use of temporary, semi-permanent and permanent fillers for acne scars. The use of permanent methylmethacrylate fillers for acne scarring is supported by a randomized controlled trial, and is approved by the United States Food and Drug Administration. There is initial evidence supporting the use of poly-L-lactic acid and hyaluronic acid fillers, but evidence is still lacking about the use of polyacrylamide and polyalkylimide fillers.
95%的痤疮患者存在痤疮瘢痕，且会导致严重的心理社会问题。填充剂常用于面部软组织填充，人们对其用于治疗痤疮瘢痕，尤其是萎缩型痤疮瘢痕的兴趣与日俱增。我们综述了使用临时、半永久和永久填充剂治疗痤疮瘢痕的证据。一项随机对照试验支持使用永久性甲基丙烯酸甲酯填充剂治疗痤疮瘢痕，且该填充剂已获美国食品药品监督管理局批准。有初步证据支持使用聚左旋乳酸和透明质酸填充剂，但关于聚丙烯酰胺和聚烷基酰亚胺填充剂的使用仍缺乏证据。
