Messini Christina I, Malandri Maria, Anifandis George, Dafopoulos Konstantinos, Georgoulias Panagiotis, Sveronis Georgios, Garas Antonios, Daponte Alexandros, Messinis Ioannis E
Department of Obstetrics and Gynaecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Department of Nuclear Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Clin Endocrinol (Oxf). 2017 Jul;87(1):44-50. doi: 10.1111/cen.13349. Epub 2017 May 11.
An inhibitory effect of ghrelin on gonadotrophin secretion has been reported in normally menstruating women possibly modulated by endogenous oestrogen. The aim of this study was to examine the effect of ghrelin on gonadotrophin and prolactin (PRL) secretion in oestrogen-deprived postmenopausal women.
Prospective intervention study.
Ten healthy postmenopausal volunteer women were studied during two 15-days periods of oestrogen treatment (A and B) a month apart. Four experiments (Exp) were performed in total, two on day 1 (Exp 1A and Exp 1B) and two on day 15 (Exp 15A and Exp 15B) of the two periods. The women received in Exp 1A and in Exp 15A two iv injections of ghrelin (0.15 μg/kg at time 0 minute and 0.30 μg/kg at time 90 minutes) and in Exp1B and in Exp 15B normal saline (2 mL), respectively. Blood samples were taken at -15, 0, 30, 60, 90, 120, 150 and 180 minutes.
After oestrogen treatment, late follicular phase serum oestradiol levels were attained on day 15 of periods A and B. Ghrelin administration did not affect serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), whereas it increased significantly those of growth hormone (GH) and PRL. In Exp 15A, serum PRL increment in response to ghrelin (area under the curve, net increment) was significantly greater than in Exp 1A (P<.05).
This study demonstrates for the first time that in oestrogen-deprived postmenopausal women, ghrelin administration affects neither FSH nor LH levels but stimulates PRL secretion, that is amplified by exogenous oestrogen administration.
已有报道称，胃饥饿素对正常月经周期女性的促性腺激素分泌具有抑制作用，这种作用可能受内源性雌激素调节。本研究的目的是检测胃饥饿素对雌激素缺乏的绝经后女性促性腺激素和催乳素（PRL）分泌的影响。
前瞻性干预研究。
10名健康的绝经后志愿女性在一个月内接受两个为期15天的雌激素治疗周期（A和B）。总共进行了四项实验（实验1、实验2），在两个周期的第1天（实验1A和实验1B）和第15天（实验15A和实验15B）各进行两项。在实验1A和实验15A中，女性分别接受两次静脉注射胃饥饿素（0分钟时0.15μg/kg，90分钟时0.30μg/kg），在实验1B和实验15B中分别接受生理盐水（2mL）。在-15、0、30、60、90、120、150和180分钟采集血样。
雌激素治疗后，在周期A和B的第15天达到卵泡晚期血清雌二醇水平。给予胃饥饿素不影响血清促卵泡生成素（FSH）和黄体生成素（LH）水平，但显著提高了生长激素（GH）和PRL水平。在实验15A中，胃饥饿素刺激引起的血清PRL增量（曲线下面积，净增量）显著大于实验1A（P<0.05）。
本研究首次证明，在雌激素缺乏的绝经后女性中，给予胃饥饿素既不影响FSH也不影响LH水平，但会刺激PRL分泌，且外源性雌激素给药会增强这种刺激作用。
