Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Department of Nuclear Medicine, Medical School, University of Thessalia, Larissa, Greece.
Fertil Steril. 2010 Sep;94(4):1478-1481. doi: 10.1016/j.fertnstert.2009.08.032. Epub 2009 Sep 26.
To investigate the effect of bromocriptine on ghrelin-induced PRL secretion in women.
Longitudinal study.
University hospital.
PATIENT(S): Ten healthy, normally cycling women.
INTERVENTION(S): The women were injected IV on day 3 of three cycles with a single dose of normal saline (cycle 1) or ghrelin (1 microg/kg) after pretreatment for 2 days either with placebo (cycle 2) or with bromocriptine (cycle 3) per os. Blood samples were taken before and frequently after drugs administration for 120 minutes.
MAIN OUTCOME MEASURE(S): The PRL and GH responses to ghrelin were assessed.
RESULT(S): Bromocriptine suppressed basal PRL levels significantly. The injection of ghrelin stimulated a significant increase in serum PRL levels in cycle 2 but not in cycle 3, in which PRL levels remained stable. The response of GH to gherlin was significantly attenuated in cycle 3 as compared with cycle 2.
CONCLUSION(S): The present study demonstrates for the first time that bromocriptine blocked the stimulating effect of ghrelin on PRL release and attenuated the GH response to the same stimulus. The mechanism of these interactions needs to be clarified.
研究溴隐亭对 ghrelin 诱导的女性 PRL 分泌的影响。
纵向研究。
大学医院。
10 名健康、正常排卵的女性。
在三个周期的第 3 天，这些女性静脉注射单剂量生理盐水（周期 1）或 ghrelin（1μg/kg），在预处理 2 天后，分别口服安慰剂（周期 2）或溴隐亭（周期 3）。在药物给药前和给药后 120 分钟内频繁采集血样。
评估 ghrelin 对 PRL 和 GH 的反应。
溴隐亭显著抑制基础 PRL 水平。ghrelin 注射刺激血清 PRL 水平在周期 2 中显著增加，但在周期 3 中没有增加，在周期 3 中 PRL 水平保持稳定。与周期 2 相比，GH 对 gherlin 的反应在周期 3 中明显减弱。
本研究首次表明，溴隐亭阻断了 ghrelin 对 PRL 释放的刺激作用，并减弱了 GH 对同一刺激的反应。这些相互作用的机制需要进一步阐明。
