Department of Biomedicine, Obstetrics and Gynaecology, Policlinico Casilino, Tor Vergata University, Rome, Italy.
Department of Cardiology, San Sebastiano Martire Hospital, Frascati, Rome, Italy.
Ultrasound Obstet Gynecol. 2018 May;51(5):672-676. doi: 10.1002/uog.17489. Epub 2018 Apr 10.
To test the efficacy of maternal activity restriction for reducing peripheral vascular resistance in normotensive pregnant women with raised total vascular resistance (TVR) and to evaluate its effect on fetal growth.
This was a prospective case-control study of 30 women enrolled between 27 and 29 weeks' gestation. All patients met the following criteria: normal blood pressure before and during pregnancy, TVR between 1300 and 1400 dynes × s/cm at enrolment, normal fetal Doppler parameters at enrolment and abdominal circumference between the 10 and 25 centiles. Patients were assigned to activity restriction (activity-restriction group; n = 15) or no treatment (control group; n = 15) and were assessed after 4 weeks for TVR and fetal growth.
TVR at enrolment and estimated fetal weight centile were similar in the activity-restriction group vs controls (1358 ± 26 vs 1353 ± 30 dynes × s/cm ; 18 ± 4 vs 19 ± 4 centile; P = NS). After 4 weeks, the activity-restriction group compared with controls showed significantly lower TVR (1165 ± 159 vs 1314 ± 190 dynes × s/cm ; P < 0.05), which was associated with higher estimated fetal weight centile (25 ± 5 vs 20 ± 5 centile; P < 0.05). TVR was lower and estimated fetal weight centile higher for the activity-restriction group after 4 weeks compared with at enrolment.
In normotensive pregnant women with raised TVR, maternal activity restriction appears to be effective in reducing TVR and therefore enhancing fetal growth. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
测试限制产妇活动对降低总血管阻力升高的正常血压孕妇外周血管阻力的疗效，并评估其对胎儿生长的影响。
这是一项前瞻性病例对照研究，共纳入 30 例妊娠 27-29 周的患者。所有患者均符合以下标准：妊娠前及妊娠期间血压正常，入组时总血管阻力（TVR）为 1300-1400 达因·秒/厘米，入组时胎儿多普勒参数正常，腹围位于第 10-25 百分位数之间。患者被分为限制活动（活动限制组；n=15）或不治疗（对照组；n=15），并在 4 周后评估 TVR 和胎儿生长情况。
活动限制组与对照组在 TVR 及估计胎儿体重百分位数方面无差异（1358±26 对 1353±30 达因·秒/厘米；18±4 对 19±4 百分位数；P=NS）。4 周后，与对照组相比，活动限制组的 TVR 显著降低（1165±159 对 1314±190 达因·秒/厘米；P<0.05），估计胎儿体重百分位数升高（25±5 对 20±5 百分位数；P<0.05）。与入组时相比，活动限制组在 4 周后 TVR 更低，估计胎儿体重百分位数更高。
在 TVR 升高的正常血压孕妇中，限制产妇活动似乎能有效降低 TVR，从而促进胎儿生长。版权所有 © 2017 ISUOG。由 John Wiley & Sons Ltd 出版。
