Department of Obstetrics and Gynaecology, University of Rome 'Tor Vergata', Rome, Italy.
Department of Obstetrics and Gynaecology, Policlinico Casilino, Rome, Italy.
Ultrasound Obstet Gynecol. 2018 Apr;51(4):514-518. doi: 10.1002/uog.17454.
To evaluate the effect on maternal cardiovascular parameters of treatment with a nitric oxide (NO) donor and plasma volume expansion in pregnancies complicated by fetal growth restriction (FGR).
Twenty-six pregnant women with a diagnosis of FGR were treated with transdermal patches of a NO donor and plasma volume expansion by co-administration of oral fluids. We compared the treated group to a historical control group of untreated FGR patients. Hemodynamic indices were obtained using the UltraSonic Cardiac Output Monitor system.
At diagnosis, the two groups were similar in terms of maternal and hemodynamic characteristics. In the treated group, we found a significant increase in maternal cardiac output and stroke volume and a decrease in systemic vascular resistance after 2 weeks of therapy. No significant differences were found 2 weeks after diagnosis in the untreated group. The treated group delivered infants with higher birth-weight centile than did the untreated control group.
The combined therapeutic approach of NO donor administration and plasma volume expansion in FGR apparently improves significantly maternal hemodynamic indices. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
评估在胎儿生长受限（FGR）孕妇中使用一氧化氮（NO）供体和血容量扩充治疗对母体心血管参数的影响。
26 名被诊断为 FGR 的孕妇接受了经皮 NO 供体贴片和口服补液联合的血容量扩充治疗。我们将治疗组与未治疗的 FGR 患者的历史对照组进行了比较。血流动力学指数采用超声心动输出监测系统获得。
在诊断时，两组在母体和血流动力学特征方面相似。在治疗组中，我们发现治疗 2 周后母体心输出量和每搏量增加，全身血管阻力降低。在未治疗组中，诊断后 2 周没有发现显著差异。治疗组的婴儿出生体重百分位比未治疗的对照组高。
NO 供体给药和 FGR 血容量扩充联合治疗方法明显改善了母体血流动力学指数。版权所有©2017 ISUOG。由 John Wiley & Sons Ltd 出版。
