Department of Psychiatry,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Department of Psychiatry,University of California at Los Angeles,Los Angeles,CA,USA.
Psychol Med. 2017 Oct;47(13):2334-2344. doi: 10.1017/S003329171700085X. Epub 2017 Apr 11.
Prior research consistently demonstrates that neuroticism increases risk for suicidal ideation, but the association between neuroticism and suicidal behavior has been inconsistent. Whereas neuroticism is recommended as an endophenotype for suicidality, the association of neuroticism with attempted suicide warrants clarification. In particular, prior research has not distinguished between correlates of attempted suicide, correlates of suicidal ideation, and correlates of comorbid psychopathology.
The present study used the CONVERGE study, a sample of 5864 women with major depressive disorder (MD) and 5783 women without MD throughout China. Diagnoses, suicidal ideation, and attempted suicide were assessed with the Composite International Diagnostic Interview (CIDI). Neuroticism was assessed with the neuroticism portion of the Eysenck Personality Questionnaire.
Results replicate prior findings on the correlates of suicidal ideation, particularly elevated neuroticism among individuals who report prior suicidal ideation. Moreover, as compared with individuals who reported having experienced only suicidal ideation, neuroticism was associated with decreased likelihood of having attempted suicide.
The association of neuroticism with suicidality is more complicated than has been previously described. Whereas neuroticism increases risk for suicidal ideation, neuroticism may decrease risk for a suicide attempt among individuals with suicidal ideation. These results have implications for the assessment of risk for a suicide attempt among individuals who report suicidal ideation and addresses prior discordant findings by clarifying the association between neuroticism and attempted suicide.
先前的研究一致表明神经质会增加自杀意念的风险，但神经质与自杀行为之间的关联并不一致。虽然神经质被推荐为自杀的内表型，但神经质与自杀未遂之间的关联仍需要澄清。特别是，先前的研究没有区分自杀未遂的相关因素、自杀意念的相关因素和共病精神病理学的相关因素。
本研究使用 CONVERGE 研究，该研究在中国对 5864 名患有重性抑郁症（MD）的女性和 5783 名没有 MD 的女性进行了研究。诊断、自杀意念和自杀未遂通过复合国际诊断访谈（CIDI）进行评估。神经质通过艾森克人格问卷的神经质部分进行评估。
结果复制了先前关于自杀意念相关因素的研究结果，特别是神经质在报告过自杀意念的个体中升高。此外，与报告只经历过自杀意念的个体相比，神经质与自杀未遂的可能性降低相关。
神经质与自杀之间的关联比以前描述的要复杂。虽然神经质会增加自杀意念的风险，但神经质可能会降低有自杀意念的个体自杀未遂的风险。这些结果对评估报告自杀意念的个体自杀未遂的风险具有重要意义，并通过澄清神经质与自杀未遂之间的关联解决了先前不一致的发现。
