NORMENT,KG Jebsen Centre for Psychosis Research,Oslo University Hospital and Institute of Clinical Medicine,University of Oslo,Oslo,Norway.
Department of Psychology,Norwegian University of Science and Technology,Trondheim,Norway.
Psychol Med. 2017 Oct;47(13):2323-2333. doi: 10.1017/S0033291717000848. Epub 2017 Apr 11.
Early trauma is linked to higher symptom levels in bipolar and psychotic disorders, but the translating mechanisms are not well understood. This study examines whether the relationship between early emotional abuse and depressive symptoms is mediated by metacognitive beliefs about thoughts being uncontrollable/dangerous, and whether this pathway extends to influence positive symptoms.
Patients (N = 261) with psychotic or bipolar disorders were assessed for early trauma experiences, metacognitive beliefs, and current depression/anxiety and positive symptoms. Mediation path analyses using ordinary least-squares regressions tested if the effect of early emotional abuse on depression/anxiety was mediated by metacognitive beliefs, and if the effect of early emotional abuse on positive symptoms was mediated by metacognitive beliefs and depression/anxiety.
Metacognitive beliefs about thoughts being uncontrollable/dangerous significantly mediated the relationship between early emotional abuse and depression/anxiety. Metacognitive beliefs and depression/anxiety significantly mediated the relationship between early emotional abuse and positive symptoms. The models explained a moderate amount of the variance in symptoms (R 2 = 0.21-0.29).
Our results indicate that early emotional abuse is relevant to depression/anxiety and positive symptoms in bipolar and psychotic disorders, and suggest that metacognitive beliefs could play a role in an affective pathway to psychosis. Metacognitive beliefs could be relevant treatment targets with regards to depression/anxiety and positive symptoms in bipolar and psychotic disorders.
早期创伤与双相情感障碍和精神病性障碍的更高症状水平有关,但翻译机制尚不清楚。本研究旨在检验早期情绪虐待与抑郁症状之间的关系是否受思维不可控/危险的元认知信念的中介,以及该途径是否会影响阳性症状。
对 261 名患有精神病性或双相情感障碍的患者进行了早期创伤经历、元认知信念以及当前抑郁/焦虑和阳性症状的评估。使用普通最小二乘法回归进行中介路径分析,以检验早期情绪虐待对抑郁/焦虑的影响是否通过元认知信念来介导,以及早期情绪虐待对阳性症状的影响是否通过元认知信念和抑郁/焦虑来介导。
思维不可控/危险的元认知信念显著中介了早期情绪虐待与抑郁/焦虑之间的关系。元认知信念和抑郁/焦虑显著中介了早期情绪虐待与阳性症状之间的关系。这些模型解释了症状变化的中等程度的方差(R 2 = 0.21-0.29)。
我们的研究结果表明,早期情绪虐待与双相情感障碍和精神病性障碍的抑郁/焦虑和阳性症状有关,并提示元认知信念可能在情感途径向精神病发展中起作用。元认知信念可能与双相情感障碍和精神病性障碍的抑郁/焦虑和阳性症状的治疗目标有关。