Huang Xue-Kun, Huang Yong-Han, Huang Juan-Hua, Liang Jing-Yao
Department of Obstetrics and Gynaecology, Reproductive Medicine Center, The First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Department of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095; Department of Dermatology, Institute of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, China.
Chin Med J (Engl). 2017 Apr 20;130(8):979-985. doi: 10.4103/0366-6999.204102.
Several studies concerning the association between glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and male infertility risk have reported controversial findings. The present study was aimed to explore this association using a meta-analysis.
The PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Wanfang databases were searched. Odds ratios (OR s) with 95% confidence intervals (CI s) were calculated to estimate the strength of the association.
A total of 3282 cases and 3268 controls in nine case-control studies were included. There was no significant association between GSTP1 Ile105Val polymorphism and male infertility in the overall population, but significant associations were found under the dominant (OR = 1.23, 95% CI = 1.04-1.46, I2 = 32.2%) and heterozygote (OR = 1.29, 95% CI = 1.08-1.53, I2 = 26.8%) models after excluding studies for which the data did not satisfy Hardy-Weinberg equilibrium (HWE). Similarly, subgroup analyses revealed no significant association in Asians or Chinese population although a significant association was apparent among Chinese population in studies with HWE under the heterozygote model (OR = 1.25, 95% CI = 1.03-1.52, I2 = 44.1%). Significant heterogeneity could be observed in some genetic models, but this heterogeneity was not significant when stratified by HWE. No evidence for publication bias was found.
The GSTP1 Ile105Val polymorphism might not be associated with male infertility risk, and thus additional well-designed studies with larger sample size are warranted.
多项关于谷胱甘肽S-转移酶P1（GSTP1）Ile105Val基因多态性与男性不育风险之间关联的研究报告了相互矛盾的结果。本研究旨在通过荟萃分析探讨这种关联。
检索了PubMed、EMBASE、中国知网（CNKI）和万方数据库。计算比值比（OR）及95%置信区间（CI）以评估关联强度。
纳入了9项病例对照研究中的3282例病例和3268例对照。在总体人群中，GSTP1 Ile105Val基因多态性与男性不育之间无显著关联，但在排除数据不满足哈迪-温伯格平衡（HWE）的研究后，在显性模型（OR = 1.23，95%CI = 1.04 - 1.46，I² = 32.2%）和杂合子模型（OR = 1.29，95%CI = 1.08 - 1.53，I² = 26.8%）下发现了显著关联。同样，亚组分析显示在亚洲人或中国人群中无显著关联，尽管在满足HWE的中国人群研究中，杂合子模型下存在显著关联（OR = 1.25，95%CI = 1.03 - 1.52，I² = 44.1%）。在某些遗传模型中可观察到显著异质性，但按HWE分层时这种异质性不显著。未发现发表偏倚的证据。
GSTP1 Ile105Val基因多态性可能与男性不育风险无关，因此有必要开展更多样本量更大、设计更完善的研究。
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